Sharif Digital Repository

As a central hub for cognitive control, prefrontal cortex (PFC) is thought to utilize memories. However, unlike working or short-term memory, the neuronal representation of long-term memory in PFC has not been systematically investigated. Using single-unit recordings in macaques, we show that PFC neurons rapidly update and maintain responses to objects based on short-term reward history. Interestingly, after repeated object-reward association, PFC neurons continue to show value-biased responses to objects even in the absence of reward. This value-biased response is retained for several months after training and is resistant to extinction and to interference from new object-reward learning... 

Background: Accurate targeting of brain areas for stimulation and/or electrophysiological recording is key in many therapeutic applications and basic neuroscience research. Nevertheless, there are currently no end-to-end packages that accommodate all steps required for exact localization, visualization, and targeting regions of interest (ROIs) using standard atlases and for designing skull implants. New Method: We have implemented a new processing pipeline that addresses this issue in macaques and humans including various preprocessing, registration, warping procedures, and 3D reconstructions, and provide a noncommercial open-source graphical software which we refer to as the MATLAB-based... 

In this study, the effect of surface modified silver nanoparticles on the corrosion protection of an epoxy coating on mild steel was studied. An organosilane (3-methoxy silyl propyl metacrylate) was used as a surface modifier to increase the dispersability of the inorganic nanoparticles in the organic epoxy coating matrix. Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) were used to characterize the surface modified nanoparticles. Differential scanning colorimetry (DSC) was employed to study the effects of modified and unmodified nano-silver on the curing heat and glass transition temperature of the epoxy coatings. Salt spray and electrochemical impedance... 

It is known that brain can create a sparse representation of the environment in both sensory and mnemonic forms (Olshausen & Field, 2004). Such sparse representation can be combined in downstream areas to create rich multisensory responses to support various cognitive and motor functions. Determining the components present in neuronal responses in a given region is key to deciphering its functional role and connection with upstream areas. One approach for parsing out various sources of information in a single neuron is by using linear blind source separation (BSS) techniques. However, applying linear techniques to neuronal spiking activity is likely to be suboptimal due to inherent and... 

To characterize the role of specimen disturbance and structure in the hydromechanical behavior of collapsible soils, two sets of wetting-induced collapse and suction-controlled triaxial tests were conducted on intact and reconstituted specimens of a loessial soil taken from a loess deposit in Gorgan, a city in the northeastern Golestan province of Iran. The testing approach used an advanced triaxial testing device that was specifically modified to control pressures applied to a soil specimen and to monitor and measure the amount of changes in volume and water content of the soil specimens during testing using highly sensitive digital sensors with an accuracy of 60.01 cm3. Results of the... 

This article mainly focuses on the characteristic, technologies and applications of cloud computing in mobile and electronic learning, and analyzes the features of this concept. We firstly tried to clarify the meaning of cloud computing as well as its features, secondly, proposed different models of using cloud computing in different learning environments, including web-based learning, mobile video learning and observational learning  

Recent evidence implicates both basal ganglia and ventrolateral prefrontal cortex (vlPFC) in encoding value memories. However, comparative roles of cortical and basal nodes in value memory are not well understood. Here, single-unit recordings in vlPFC and substantia nigra reticulata (SNr), within macaque monkeys, revealed a larger value signal in SNr that was nevertheless correlated with and had a comparable onset to the vlPFC value signal. The value signal was maintained for many objects (>90) many weeks after reward learning and was resistant to extinction in both regions and to repetition suppression in vlPFC. Both regions showed comparable granularity in encoding expected value and value... 

Ecological fitness depends on maintaining object histories to guide future interactions. Recent evidence shows that value memory changes passive visual responses to objects in ventrolateral prefrontal cortex (vlPFC) and substantia nigra reticulata (SNr). However, it is not known whether this effect is limited to reward history and if not how cross-domain representations are organized within the same or different neural populations in this corticobasal circuitry. To address this issue, visual responses of the same neurons across appetitive, aversive and novelty domains were recorded in vlPFC and SNr. Results showed that changes in visual responses across domains happened in the same rather... 

Labyrinth side weirs provide a potentially effective way to shorten the length of a channel opening with the desired water height, but the discharge coefficient needs to be found experimentally. Experiments were carried out for triangular labyrinth side weirs with one and two cycles in order to obtain the discharge coefficient. The test variables included channel opening, head angle, number of cycles, weir height, upstream water depth and discharge in a subcritical situation. The resultsshow that the discharge coefficient ratio for a triangular labyrinth to a conventional side weir could rise to more than 2 with the same flow and geometric conditions. Relationships for the De Marchi... 

The design, simulation and fabrication of a planar fragmented loop antenna with capacitive loads at 60 GHz frequency band is reported in this paper. The loop antenna has a nearly omni-directional radiation pattern required for many IEEE 802.11ad applications, a simulated bandwidth of 6 GHz, and a realized gain of 2 dBi. The measured input matching bandwidth without deembedding the connector effect is nearly 2 GHz. The HPBW in azimuth plane is 360°.s  

A wideband integrated delay chain chip with 5-bit main delay control, two error correction bits, maximum delay of 125-and 3.9-ps delay resolution, designed and fabricated in a 0.18-μ m CMOS technology is presented. This delay chain is a cascade of seven passive internal-switched delay blocks which the five main bits are based on novel delay structures. The proposed delay structures are similar to second-, fourth-, and sixth-order all-pass networks and are robust to mismatch effects of resistive parasitics of transistor switches. Measurement results of the fabricated delay chain show 15.2-23.3-dB insertion loss and less than 3.3-ps rms delay error over the intended frequency band from 8-18... 

A novel trombone topology has been introduced for achieving controllable true time delay. The prominent aspect of the proposed topology is the ability to provide discrete variable delay with minimum insertion loss variation with delay settings. Furthermore, the effects of source impedance, output load, and line-terminating loads' impedance mismatch on group delay variation are theoretically investigated for the proposed trombone topology. Moreover, based on this new topology, a prototype trombone delay circuit has been designed and fabricated in 0.18- mu ext{m} CMOS technology, operating over the frequency bandwidth of 8-18 GHz. This 3-bit delay integrated circuit provides a maximum delay... 

A high-precision delay chain circuit integrated in a 0.18- mu ext{m} CMOS technology working in the frequency bandwidth of 8-18 GHz has been designed and tested. The designed delay control integrated circuit with 5-bit delay control provides a maximum delay of 125 ps and has a delay resolution of 3.9 ps. Measured delay error of the fabricated chip is less than 9.3%, making it a considerably accurate delay control circuit. Low delay-error performance has resulted from incorporating a novel delay cell in this delay chain circuit. This newly proposed delay cell is a lumped-element coupled transmission line loaded with a second-order all-pass network (APN). The APN-loaded coupled line delay... 

A wideband integrated delay chain chip with 5-bit main delay control, two error correction bits, maximum delay of 125-and 3.9-ps delay resolution, designed and fabricated in a 0.18-μ m CMOS technology is presented. This delay chain is a cascade of seven passive internal-switched delay blocks which the five main bits are based on novel delay structures. The proposed delay structures are similar to second-, fourth-, and sixth-order all-pass networks and are robust to mismatch effects of resistive parasitics of transistor switches. Measurement results of the fabricated delay chain show 15.2-23.3-dB insertion loss and less than 3.3-ps rms delay error over the intended frequency band from 8-18... 

Supplying non-linear loads causes increased losses in transformers which eventually leads to their reduced life spans. Therefore, transformers are derated in order to protect them against premature loss of life. To do this, load losses including ohmic loss and winding eddy current (WEC) loss need to be estimated. This study suggests an improved analytical approach using finite element method (FEM) which includes all material characteristics and geometrical structures in order to calculate WEC loss under non-sinusoidal load current in each winding individually. By adopting this procedure, harmonic loss factor as a dominant parameter in transformers derating is estimated. By emphasising the... 

Electroencephalogram (EEG) is a noninvasive, low-cost brain recording tool with high temporal but poor spatial resolution. In contrast, functional magnetic resonance imaging (fMRI) is a rather expensive brain recording tool with high spatial and poor temporal resolution. In this study, we aim at recovering the brain activity (source localization and activity-intensity) with high spatial resolution using only EEG recordings. Each EEG electrode records a linear combination of the activities of various parts of the brain. As a result, a multi-electrode EEG recording represents the brain activities via a linear mixing matrix. Due to distance attenuation, this matrix is almost sparse. Using... 

Memory and motor deficits are commonly identified in Parkinson's disease (PD). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is transformed to MPP+ via monoamine oxidase B (MAOB), which causes oxidative stress and destroys dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) and is widely used to create animal models of PD. However, to-date, a comprehensive analysis of the MPTP effects on various aspects of PD does not exist. Here, we provide a systematic review and meta-analysis on the MPTP effects on memory and motor functions by analyzing 51 studies on more than one thousand animals mainly including rats and mice. The results showed that in addition to motor functions... 

Simultaneous recording of activity across brain regions can contain additional information compared to regional recordings done in isolation. In particular, multivariate pattern analysis (MVPA) across voxels has been interpreted as evidence for distributed coding of cognitive or sensorimotor processes beyond what can be gleaned from a collection of univariate effects (UVE) using functional magnetic resonance imaging (fMRI). Here, we argue that regardless of patterns revealed, conventional MVPA is merely a decoding tool with increased sensitivity arising from considering a large number of ‘weak classifiers’ (i.e., single voxels) in higher dimensions. We propose instead that ‘real’ multivoxel...