Loading...

Design and Fabrication of a Hybrid Piezoelectric Bone Scaffold using Melt Electrowriting (MEW) of PCL and FDM Printing of PVDF

Fazel Modarres, Sina | 2025

13 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 58744 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Mohammadi, Kaivan
  7. Abstract:
  8. The ability to fabricate scaffolds that closely resemble the structural characteristics of natural bone remains one of the major challenges in bone tissue engineering. Moreover, developing materials for scaffold fabrication that can accelerate the regeneration process is another important issue. A hybrid scaffold was developed in this study using Melt electrowriting (MEW) and fused deposition modeling (FDM) techniques to mimic the hierarchical architecture of natural bone, consisting of cancellous and cortical regions. The cancellous region was fabricated via MEW using polycaprolactone (PCL), while the cortical region was produced through FDM employing polyvinylidene fluoride (PVDF). The two sections were subsequently integrated to form the complete scaffold. The incorporation of PVDF enabled cellular stimulation under mechanical loading, thereby enhancing cell growth within the scaffold. These hybrid scaffolds were also compared with scaffolds fabricated using the FDM. The results of compressive mechanical testing showed that the scaffolds with a PVDF shell exhibited the highest compressive strength, with a value of 70.9 MPa. Furthermore, tensile testing indicated that the PCL (MEW) exhibited the highest strain tolerance, with an ultimate tensile strength of 6.95 MPa. In addition, MTT assay revealed high cell viability, with values of 92% for the hybrid scaffold and 87% for PCL (FDM). Consequently, an improved scaffold was proposed for application in bone tissue regeneration
  9. Keywords:
  10. Bone Tissue Engineering ; Bone Scaffold ; Fused Deposition Modeling (FDM) ; Polyvinylidene Fluoride (PVDF) ; Polycaprolactone Composite ; Melt Electrowriting (MEW) ; Three Dimentional Printing

 Digital Object List

 Bookmark

No TOC