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  1. بررسی دارورسانی به تومورهای سرطانی تحت تأثیر میدان مغناطیسی
بررسی دارورسانی به تومورهای سرطانی تحت تأثیر میدان مغناطیسی
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بررسی دارورسانی به تومورهای سرطانی تحت تأثیر میدان مغناطیسی

محمدیان، علی محمد Mohammadian, Ali Mohammad

Investigation of Drug Delivery to Cancer Tumors under the Influence of Magnetic Field

Mohammadian, Ali Mohammad | 2025

556 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: English
  3. Document No: 58415 (58)
  4. University: Sharif University of Technology, International Campus, Kish Island
  5. Department: Science and Engineering
  6. Advisor(s): Shamloo, Amir; Sadrhosseini, Hani
  7. Abstract:
  8. This is a Computational Fluid Dynamics research on delivering drugs to cancerous tumors, by encapsulating drug particles within ferromagnetic particles and exposing them to an external magnetic field. The study explores the impact of the magnetic field on the efficacy of drug delivery, and whether it can enhance the drug concentration while reducing side effects. For creation of the geometry of the tumor, image processing techniques on a tumor image was used, which allowed for the construction of a network of tumor vessels based on the images. The desired results were then achieved by coupling the magnetic field with the flow of the magnetic fluid and the movement of particles. The research was conducted over a time frame of one second, with 0.1 s time steps. The findings revealed that the presence of the drug at the tumor site increased by 89% compared to when there was no magnetic field. The magnetic field diverted the drugs from the exit route, leading to a more uniform distribution of drugs on the tumor surface and less accumulation in healthy tissues. While the study did not encompass all necessary aspects, it indicates that this method holds promise. It could be further studied and potentially applied to other local diseases, in addition to cancer and particularly cancerous tumors
  9. Keywords:
  10. Drug Delivery ; Tumors ; External Magnetic Field ; Cancer Treatment ; Targeted Druy Delivery

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