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شبیه سازی فرایند تولید پلیمر زیست تخریب پذیر پلی هیدروکسی بوتیرات (PHB) با استفاده از بیوراکتور ستون حبابی
کردوانی، محمد رضا Kordavani, Mohammad Reza
Simulation of the Production Process of Polyhydroxybutyrate (PHB) Biodegradable Polymer via a Bubble Column Bioreactor
Kordavani, Mohammad Reza | 2025
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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 58173 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Askaripour, Hossein
- Abstract:
- In this study, the biological process of producing polyhydroxybutyrate (PHB), a biodegradable polymer, using methane as the carbon source and nitrate as the nitrogen source was numerically modeled and simulated in an 8 m height and 0.5 m diameter bubble column bioreactor. The primary goal was to develop a time-dependent model capable of simultaneously describing biomass growth, substrate consumption, and polymer production, while accounting for gas–liquid mass transfer and momentum transfer. The modeling was performed under sufficient aeration, and any complications arising from strain swelling due to intracellular accumulation were neglected. Initially, a biomass growth model based on a zero-order reaction with methane as the sole substrate was validated. The model’s accuracy was evaluated by examining variations in methane and biomass concentrations. Subsequently, a two-substrate model was developed that considered the simultaneous consumption of methane and nitrate, with the onset of polymer synthesis linked to a critical nitrate concentration. The governing equations were numerically solved using COMSOL, and a mesh independence analysis was conducted to ensure computational accuracy. Based on the mesh independence study, a medium mesh with 26,031 elements was selected. The results demonstrated that the proposed model can accurately predict system behavior under different operating conditions and can serve as a useful tool for designing and optimizing biopolymer production processes from methane. Furthermore, an intermittent feeding strategy was introduced as an effective approach to control nitrogen limitation and enhance PHB productivity. Simulating one cycle of this strategy yielded a dry weight percentage of 8.5%, which is considered satisfactory and promising for a single short-duration cycle
- Keywords:
- Polyhydroxybutyrate ; Biodegradable Polymer ; Bubble Column Bioreactor ; Simulation ; Monod Model with Two Substrates ; Methanotrophic Strain
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