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Novel multifunctional bioactive glass incorporated alginate/poly(amidoamine) hydrogels with controlled drug release for cartilage tissue regeneration

Motesadi Zarandi, F ; Sharif University of Technology | 2024

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  1. Type of Document: Article
  2. DOI: 10.1007/s10853-023-09275-9
  3. Publisher: 2024
  4. Abstract:
  5. Tissue engineering faces an intriguing challenge in creating biomaterials for cartilage repair. Within the category of biopolymeric scaffolds, hydrogels made from polysaccharides are particularly suitable for regenerating cartilage tissue. In this paper, a new formulation of biocompatible alginate-based hydrogel for joint cartilage regeneration was investigated. An alginate-dendrimer hydrogel obtained by covalently grafting alginate with polyamidoamine generation 5 dendrimer. 58S bioactive glass was synthesized through sol–gel procedures and was added to the hydrogel before cross-linking. The obtained hydrogel is an innovative system with sustained drug-releasing properties and improved mechanical behavior in comparison to the alginate matrix. For instance, the tensile and compressive modulus of the fabricated composite hydrogel increased from 0.035 to 0.072 MPa and 0.17 to 0.40 MPa respectively. Whereas the degradation ratio decreased from 0.26 to 0.09% by the addition of polyamidoamine and bioactive glass. The developed hydrogel also showed better properties in in-vitro studies such as swelling and degradation. MTT assay showed no toxicity and revealed the biocompatibility of prepared hydrogel. The MTT test, also performed better adhesion of cells by the addition of bioactive glass powder. The composite hydrogel loaded with tetracycline hydrochloride showed more sustained drug-release behavior and excellent antibacterial properties compared to bear alginate hydrogel. Therefore, the Alginate/polyamidoamine/bioactive glass hydrogel can couple the well-known bioactive properties of 58S bioactive glass with good biocompatibility of alginate-dendrimer hydrogels, opening new approaches in the field of tissue engineering. Graphical abstract: [Figure not available: see fulltext.] © 2024, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature
  6. Keywords:
  7. Alginate ; Bioactive glass ; Biocompatibility ; Biopolymers ; Cartilage ; Controlled drug delivery ; Scaffolds (biology) ; Sols ; Targeted drug delivery ; Tissue regeneration ; 58S bioactive glass ; Cartilage regeneration ; Cartilage repair ; Cartilage tissues ; Composite hydrogels ; Controlled drug release ; Joint cartilage ; Polyamidoamines ; Property ; Tissues engineerings ; Hydrogels
  8. Source: Journal of Materials Science ; Volume 59, Issue 4 , 2024 , Pages 1550-1569 ; 00222461 (ISSN)
  9. URL: https://link.springer.com/article/10.1007/s10853-023-09275-9