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Investigation of gadolinium doped manganese nano spinel ferrites via magnetic hypothermia therapy effect towards MCF-7 breast cancer

Tahir, M ; Sharif University of Technology | 2024

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  1. Type of Document: Article
  2. DOI: 10.1016/j.heliyon.2024.e24792
  3. Publisher: Elsevier , 2024
  4. Abstract:
  5. Magnetic spinel ferrite nanoparticles (MSF-NPs) are potential candidates for biomedical applications, especially in cancer diagnosis and therapy due to their excellent physiochemical and magnetic properties. In the current study, MSF-NPs were fabricated by sol-gel auto combustion method. The crystal structure and surface morphology were confirmed by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The magnetic properties were studied by VSM (vibrating sample magnetometer). As increasing Gd3+ concentration, the saturation magnetization values decreased from (17.8-2.3) emu/g, while the coercivity decreased from (499-133) Oe at room temperature. Finally, the fabricated MSF-NPs were tested against anticancer activity by MTT assay. The IC50 = 21.27 μg/mL value was observed, showing the strong antiproliferative activity of these nanoparticles. These results suggested that the obtained MSF-NPs would be useful for remote-controlled hyperthermia therapy for cancer treatment and MRI application due to their excellent magnetic properties. These distinct properties make MSF-NPs most suitable for cancer treatment and bright Contrast Agents (T1-MRI). © 2024 The Authors
  6. Keywords:
  7. Magnetic hyperthermia therapy ; Magnetic spinal ferrites ; MRI ; VSM and MCF-7
  8. Source: Heliyon ; Volume 10, Issue 3 , 2024 ; 24058440 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S2405844024008235