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  1. Virulence factors of the zoonotic pathogen vibrio alginolyticus: A review and bibliometric analysis

Virulence factors of the zoonotic pathogen vibrio alginolyticus: A review and bibliometric analysis

Sheikh, H. I ; Sharif University of Technology | 2024

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  1. Type of Document: Article
  2. DOI: 10.1134/S0003683823602822
  3. Publisher: 2024
  4. Abstract:
  5. Abstract: Vibrio alginolyticus is an opportunistic Gram-negative marine bacterium that infects animals and humans. Its virulence is associated with numerous factors such as cytotoxicity, adhesion and biofilm formation. This review aimed to quantitatively assess the V. alginolyticus’s virulence factors to identify the main mechanisms of infection. A systematic literature search was conducted using SCOPUS databases up to 31 December 2022. The bibliometric analysis was performed using VOSviewer software. The results showed that toxins are the most common virulence factor making up more than 50% of virulence-related keywords. This was followed by adhesion/biofilm (12%), antibiotic resistance (9%) and quorum sensing (9%). In terms of cytotoxicity, hemolysins were the most common toxins, while in terms of secretion system, type III secretion system (T3SS) was the most common. Extracellular polysaccharide production was the main parameter related to adhesion and biofilm. In terms of antibiotic resistance, extended-spectrum β-lactamases (ESBLs) genes were the most common, and for quorum sensing, N-acyl homoserine lactone (AHL) was the most common. Vibrio pathogenicity island was also identified as a mechanism for accumulating virulence factors. Toxin-coregulated pilus (Tcp) was identified as the main motility-related virulence factor. This review reports that quorum sensing and kinase inhibitors are promising drug targets. Identifying these mechanisms can help in establishing ideal drug targets and management approaches for V. alginolyticus-related infections. © Pleiades Publishing, Inc. 2024. ISSN 0003-6838, Applied Biochemistry and Microbiology, 2024, Vol. 60, No. 3, pp. 514–531. Pleiades Publishing, Inc., 2024. ISSN 0003-6838, Applied Biochemistry and Microbiology, 2024. Pleiades Publishing, Inc., 2024
  6. Keywords:
  7. Pathogenicity ; VOSviewer ; Zoonotic bacteria ; Accessory cholera enterotoxin ; Alkaline serine protease ; Amylase ; Bacterial protein ; Cholera toxin ; Collagenase ; Elastase ; Endopeptidase Clp ; Exopolysaccharide ; Extended spectrum beta lactamase ; Extracellular polymeric substance ; Extracellular protease ; Gelatinase ; Hemolysin ; Iron ; Microbial products not classified elsewhere ; N acylhomoserine lactone ; Outer membrane protein ; Phosphotransferase inhibitor ; Proteinase ; Serine proteinase ; Toxin coregulated pilus ; ToxR protein ; ToxS protein ; ToxT protein ; Triacylglycerol lipase ; Unclassified drug ; Urease ; Virulence factor ; Zonula occludens toxin ; Antibiotic resistance ; Bacterial virulence ; Bacterium adherence ; Bibliometrics ; Bioaccumulation ; Biofilm ; Cytotoxicity ; Data analysis ; Drug targeting ; Human ; Information processing ; Nonhuman ; Pathogenicity island ; Plasmid ; Publication ; Quorum sensing ; Scopus ; Systematic review ; Twitching motility ; Type III secretion system ; Type VI secretion system ; Vibrio alginolyticus ; Vibriosis
  8. Source: Applied Biochemistry and Microbiology ; Volume 60, Issue 3 , 2024 , Pages 514-531 ; 00036838 (ISSN)
  9. URL: https://link.springer.com/article/10.1134/S0003683823602822