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Engineered robust hydrophobic/hydrophilic nanofibrous scaffolds with drug-eluting, antioxidant, and antimicrobial capacity

Soleimani, F ; Sharif University of Technology | 2024

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  1. Type of Document: Article
  2. DOI: 10.1021/acsabm.4c00025
  3. Publisher: 2024
  4. Abstract:
  5. Multifunctional nanofibrous architectures have attracted extensive attention for biomedical applications due to their adjustable and versatile properties. Electrospun fabrics stand out as key building blocks for these structures, yet improving their mechanobiological and physicochemical performance is a challenge. Here, we introduce biodegradable engineered hydrophobic/hydrophilic scaffolds consisting of electrospun polylactide nanofibers coated with drug-eluting synthetic (poly(vinyl alcohol)) and natural (starch) polymers. The microstructure of these composite scaffolds was tailored for an increased hydrophilicity, optimized permeability, water retention capacity of up to 5.1 g/g, and enhanced mechanical properties under both dry and wet conditions. Regarding the latter, normalized tensile strengths of up to 32.4 MPa were achieved thanks to the improved fiber interactions and fiber-coating stress transfer. Curcumin was employed as a model drug, and its sustained release in a pure aqueous medium was investigated for 35 days. An in-depth study of the release kinetics revealed the outstanding water solubility and bioavailability of curcumin, owing to its complexation with the hydrophilic polymers and further delineated the role of the hydrophobic nanofibrous network in regulating its release rate. The modified curcumin endowed the composites with antioxidant activities up to 5.7 times higher than that of free curcumin as well as promising anti-inflammatory and bacteriostatic activities. The cytocompatibility and cell proliferation capability on human dermal fibroblasts also evidenced the safe use of the constructs. Finally, the fabrics present pH-responsive color-changing behavior easily distinguishable within the pH range of 5-9. Thus, these designs offer a facile and cost-effective roadmap for the fabrication of smart multifunctional biomaterials, especially for chronic wound healing. © 2024 American Chemical Society
  6. Keywords:
  7. Antibacterial ; Anti-Bacterial Agents ; Biocompatible Materials ; Fibroblasts ; Humans ; Hydrophobic and Hydrophilic Interactions ; Microbial Sensitivity Tests ; Particle size ; Polyesters ; Antioxidants ; Biochemistry ; Biodegradable polymers ; Biopolymers ; Cell culture ; Controlled drug delivery ; Cost effectiveness ; Electrospinning ; Hydrophilicity ; Hydrophobicity ; Mechanical permeability ; Medical applications ; Nanofibers ; Physicochemical properties ; Polyvinyl alcohols ; Scaffolds (biology) ; Starch ; Targeted drug delivery ; Tensile strength ; Antiinfective agent ; Antioxidant ; Biomaterial ; Nanofiber ; Polyester ; Antibacterials ; Biomedical applications ; Building blockes ; Curcumin ; Electrospuns ; Hydrophobic-hydrophilic ; Nano-fibrous ; Nanofibrous scaffolds ; Property ; Wound healing ; Cell survival ; Chemical phenomena ; Chemistry ; Drug effect ; Escherichia coli ; Fibroblast ; Human ; Materials testing ; Microbial sensitivity test ; Staphylococcus aureus ; Cell proliferation
  8. Source: ACS Applied Bio Materials ; Volume 7, Issue 6 , 2024 , Pages 3687-3700 ; 25766422 (ISSN)
  9. URL: https://pubs.acs.org/doi/10.1021/acsabm.4c00025