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Numerical simulation of nanoneedle-cell membrane collision: minimum magnetic force and initial kinetic energy for penetration

Rostami, M ; Sharif University of Technology | 2024

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  1. Type of Document: Article
  2. DOI: 10.1088/2057-1976/ad5019
  3. Publisher: 2024
  4. Abstract:
  5. Aims and objectives: This research aims to develop a kinetic model that accurately captures the dynamics of nanoparticle impact and penetration into cell membranes, specifically in magnetically-driven drug delivery. The primary objective is to determine the minimum initial kinetic energy and constant external magnetic force necessary for successful penetration of the cell membrane. Model Development: Built upon our previous research on quasi-static nanoneedle penetration, the current model development is based on continuum mechanics. The modeling approach incorporates a finite element method and explicit dynamic solver to accurately represent the rapid dynamics involved in the phenomenon. Within the model, the cell is modeled as an isotropic elastic shell with a hemiellipsoidal geometry and a thickness of 200 nm, reflecting the properties of the lipid membrane and actin cortex. The surrounding cytoplasm is treated as a fluid-like Eulerian body. Scenarios and Results: This study explores three distinct scenarios to investigate the penetration of nanoneedles into cell membranes. Firstly, we examine two scenarios in which the particles are solely subjected to either a constant external force or an initial velocity. Secondly, we explore a scenario that considers the combined effects of both parameters simultaneously. In each scenario, we analyze the critical values required to induce membrane puncture and present comprehensive diagrams illustrating the results. Findings and significance: The findings of this research provide valuable insights into the mechanics of nanoneedle penetration into cell membranes and offer guidelines for optimizing magnetically-driven drug delivery systems, supporting the design of efficient and targeted drug delivery strategies. © 2024 IOP Publishing Ltd
  6. Keywords:
  7. Drug delivery ; Finite element method ; Magnetic field ; Drug Delivery Systems ; Humans ; Magnetics ; Models, Biological ; Nanoparticles ; Needles ; Cells ; Continuum mechanics ; Controlled drug delivery ; Cytology ; Kinetic energy ; Membranes ; Numerical methods ; Proteins ; Targeted drug delivery ; Actin ; Nanoneedle ; Nanoparticle ; Cell penetration ; Initial kinetics ; Kinetic constant ; Kinetic models ; Magnetic-field ; Model development ; Nanoparticle impacts ; Primary objective ; Quasi-static ; Cell membrane ; Comparative study ; Controlled study ; Critical value ; Cytoplasm ; Drug penetration ; Energy ; Female ; Finite element analysis ; Force ; Geometry ; HeLa cell line ; Human ; Human cell ; KKinetic energy ; Kinetics ; Lipid membrane ; Magnetic force ; Mechanical stress ; Mechanics ; Molecular dynamics ; Numerical simulation ; Oscillation ; Particle size ; Velocity ; Viscoelasticity ; Biological model ; Chemistry ; Computer simulation ; Drug delivery system ; Magnetism ; Metabolism ; Needle ; Magnetic fields
  8. Source: Biomedical Physics and Engineering Express ; Volume 10, Issue 4 , 2024 ; 20571976 (ISSN)
  9. URL: https://iopscience.iop.org/article/10.1088/2057-1976/ad5019