2D electrical admittance lattice model of biological cellular system for modeling electroporation

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Barati, H

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Type of Document: Article
DOI: 10.1016/j.bpj.2024.07.016
Publisher: 2024
Abstract:
In this work, a new modeling approach is presented to obtain a two-dimensional transport lattice of a biological cellular system for the calculation of the potential distribution throughout the system and investigation of the corresponding membrane electroporation. The presented model has been obtained by a modified bilayer model of the cell membrane. This modified membrane model allows for an effective inclusion of the shape of the cell membrane in the potential calculation. The results of the model have shown good agreement with the results of the well-known Schwan equation and COMSOL Multiphysics for the circular cell. The simulation results show that both membranes of a mitochondrion can be simultaneously electroporated by an alternating voltage source with frequencies between 1 MHz and 1 GHz. © 2024 Biophysical Society
Keywords:
Mitochondria ; Models, biological ; Biological model ; Cell membrane ; Chemistry ; Computer simulation ; Electroporation ; Lipid bilayer ; Membrane potential ; Metabolism ; Mitochondrion
Source: Biophysical Journal ; Volume 123, Issue 18 , 2024 , Pages 3176-3187 ; 00063495 (ISSN)
URL: https://www.sciencedirect.com/science/article/pii/S0006349524004752