Loading...

Evaluation of the anti-cholelithiasis activity of vinegar-soaked Ficus carica fruit in adults: a randomized controlled trial

Bukhari, M ; Sharif University of Technology | 2024

88 Viewed
  1. Type of Document: Article
  2. DOI: 10.36721/PJPS.2024.37.6.REG.1411-1419.1
  3. Publisher: 2024
  4. Abstract:
  5. This study aimed to evaluate the efficacy of vinegar-soaked Ficus carica fruits (VSFCF) for managing cholelithiasis in adults. A parallel-group, single-blinded, randomized controlled trial at Noreen Nishat Welfare Hospital, Khanewal, Pakistan, was conducted from December 2023 to February 2024. Fifty adults with ultrasound-confirmed cholelithiasis were randomly assigned to receive either VSFCF (1 g/kg/day) or ursodiol (600 mg/day). Primary outcomes included gallstone size reduction, while secondary outcomes assessed symptom relief (pain, bloating, digestive discomfort) and hepatic markers. Data analysis was performed using SPSS with a significance level set at P<0.05. Results indicated a significant reduction in gallstone size in the VSFCF group, with mean sizes decreasing from 15.5± 2.3 mm to 7.3±1.0 mm (P<0.001), compared to a decrease from 16.1±2.5 mm to 10.8±1.5 mm (P<0.01) in the ursodiol group. Additionally, VSFCF significantly improved symptoms and hepatic markers, with P-values ranging from <0.05 to <0.001. These findings suggest that VSFCF is an effective alternative for reducing gallstone size and improving symptoms and hepatic health in cholelithiasis management. © 2024 Pakistan Journal of Pharmaceutical Sciences. All rights reserved
  6. Keywords:
  7. Ficus carica ; Gallstones ; Hepatic enzymes ; Vinegar ; Single-blind method ; Anticholelithiasis agent ; Unclassified drug ; Ursodeoxycholic acid ; Vinegar soaked ficus carica fruit ; Acetic acid ; Plant extract ; Anti cholelithiasis activity ; Bloating ; Clinical article ; Controlled study ; Drug activity ; Drug efficacy ; Echography ; Gallstone size ; Gastrointestinal symptom ; Pain ; Pakistan ; Remission ; Size ; Therapy effect ; Chemistry ; Cholelithiasis ; Drug therapy ; Ficus ; Fruit ; Middle aged ; Randomized controlled trial ; Single blind procedure ; Treatment outcome
  8. Source: Pakistan Journal of Pharmaceutical Sciences ; Volume 37, Issue 6 , 2024 , Pages 1411-1419 ; 1011601X (ISSN)
  9. URL: https://www.pjps.pk/uploads/2025/01/1736487684.pdf