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SimDFBA: A framework for bioprocess simulation and development

Sohrabi Shoabjareh, A ; Sharif University of Technology | 2023

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  1. Type of Document: Article
  2. DOI: 10.1016/j.compchemeng.2022.108073
  3. Publisher: Elsevier Ltd , 2023
  4. Abstract:
  5. Many efforts have been made to model bio-processes and investigate the main effective parameters using conventional known softwares. The main shortcoming of such models is that the bioreactor is considered a black box. Such simplification causes uncertainty in following different metabolic pathways of microorganisms. This study presents a new method for simulating bio-processes by integrating available conventional simulation softwares such as ASPEN PLUS and MATLAB. The former is used to simulate common process equipment, and the latter is employed to model Bio-reactor. Besides, the Bio-reactor is modeled mathematically with Dynamic Flux Balance Analysis (DFBA) concept using the metabolic network reconstruction model. This framework will simultaneously provide a rigorous basic model of both upstream and downstream equipment. This approach can also be used as a toolbox to implement process optimization and modern control strategies on the bio-processes. A syngas fermentation bioprocess case study was chosen to implement the new framework. © 2022
  6. Keywords:
  7. Bioprocess ; Ethanol ; FBA ; Gas fermentation ; Simulation ; Syngas
  8. Source: Computers and Chemical Engineering ; Volume 169 , 2023 ; 00981354 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0098135422004057