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Design and Fabrication of Self-Healable Double-Network (DN) Hydrogels Based on Reversible and Irreversible Bonds with Tunable Mechanical Properties

Aghajani Mongari, Mohammad Ali | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54013 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Pourjavadi, Ali
  7. Abstract:
  8. In order to increase the mechanical properties and resistance of hydrogels to external damage, for their wide application in tissue engineering and medicine, self-healing two-grid hydrogels are used. Two-grid hydrogels with physical lattice have more advantages than two-grid hydrogels with chemical lattice because they have reversible and dynamic bonds, which in addition to increasing mechanical properties, also have self-healing properties. In order to achieve high mechanical properties, gelatin-based double-grid hydrogels with hydrogen bonding and metal-ligand interaction are designed. In the present paper, two-grid hydrogels consisting of gelatin network and other network of sodium 2-acrylamido-2-methylpropane sulfonic acid-co-2- (dimethylamino) ethyl methacrylate are formed. In this structure, hydrogen bonding and metal-ligand interaction are used as reversible bonds to create self-healing properties. Based on mechanical stress and tensile tests, metal-ligand interaction has a greater effect on improving the mechanical properties and stability of hydrogels. In addition, scanning electron microscopy images of interwoven hydrogels (without iron ions) and entwined (in the presence of iron ions) showed that the addition of ferric citrate to the interwoven hydrogel reduced the pore size and affected its mechanical properties and water absorption. All the mentioned properties can be adjusted by changing the amount of methylene base acrylamide chemical network and physical network of ferric citrate. By irradiating light on the ferric ion double-grid hydrogel, the iron ion was converted to ferrous iron, and the mechanical and swelling properties of the hydrogel were similar to those of a semi-IPN hydrogel, which showed high biodegradability in its swelling behavior
  9. Keywords:
  10. Self Healing Hydrogel ; Metal-Ligand Interaction ; Adjustable Mechanical Properties ; Semi-Interwoven Hydrogel ; Interwoven Hydrogel ; Tissue Engineering

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