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Recovering the mechanical properties of denatured intervertebral discs through Platelet-Rich Plasma therapy

Khalaf, K ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1109/EMBC.2015.7318516
  3. Publisher: Institute of Electrical and Electronics Engineers Inc , 2015
  4. Abstract:
  5. Degenerative disc disease is one of the most common causes of low back pain instigating huge socioeconomic costs and posing an immense burden on healthcare systems worldwide. New therapeutic approaches to damaged intervertebral discs are therefore of great interest. Platelet-Rich Plasma (PRP) has been proposed for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding its effectiveness and influence on disc material properties. The objective of this study was to investigate and quantify the material properties of intact, denatured, and PRP treated discs. A systematic methodology was established in the process, where ex-vivo experiments were conducted and material properties were extracted using an inverse finite element approach. The results showed that PRP is able to recover the mechanical properties of denatured discs, thereby providing a promising effective therapeutic modality
  6. Keywords:
  8. Source: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 25 August 2015 through 29 August 2015 ; Volume 2015-November , 2015 , Pages 933-936 ; 1557170X (ISSN) ; 9781424492718 (ISBN)
  9. URL: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7318516