Sharif Digital Repository

We have reported a new and efficient synthesis of a broad spectrum of heterotetracyclic benzoxazocines via unique tandem 1,3-dinucleophilic addition of different bifunctional nucleophiles to quinolinium and isoquinolinium salts. The reaction generally involves the initial addition of nucleophiles to quinolinium salts to form enamine intermediate which can be trapped by intramolecular O/S-alkylation of nucleophiles. In the third part, as continues, we have reported another method which consists of Anthocyanidins and Thioindoles by using water and acetic acid as the solvent. This protocol is a very mild and simple method for construction of eight-membered ring in fused heterocycles in a... 

In the first chapter of the thesis the synthesis of indolylsulfanyl acetamide derivatives using thio-oxindoles has been reported. The properties of this reaction are, one-pot, without using catalysts, acetonitrile solvent and the raw material is available. This reaction has high yield and seperation products is done using column chromatography. Indole derivatives has various medicinal and biological properties and synthetic products in this project has indole ring, aldehyde and amide functional groups. In the second chapter of the thesis, a new magnetic nanocatalyst has been designed. The magnetic nanoparticles were coated with triazole ligand and then palladium (II) ion was loaded onto the... 

Heterocyclic compounds participate in a wide range of reactions, and a large number of them are known. These compounds differ in size and number of rings, type and number of heteroatoms and position of heteroatoms. In the meantime, nitrogen-containing heterocyclic compounds have been widely used in the pharmaceutical and agricultural industries due to their high biological activity. Thioxindole, a cyclic thioamide compound, has been recognized as a biologically active compound and its importance and impact in the development of chemistry are growing. In this thesis, 2-chloroquinoline-3-carbaldehyde is synthesized on acetanilide via Vilsmeier-Haack reaction, a classical reaction in organic...