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Synthesis of Spiro Polycyclic Heterocycles Using Isatin and Designing Iron Oxide-based Heterogeneous Nano Catalyst for Organic Transformations under Green Chemistry Conditions
, Ph.D. Dissertation Sharif University of Technology ; Matloubi Moghaddam, Firouz (Supervisor) ; Balalai, Saeed (Co-Supervisor)
Abstract
Spirocycles have been employed both as core structures and appended to the periphery of molecules in drug discovery. The major advantage that spirocycles offer as core structures is their inherent three-dimensional nature and concomitant ability to project functionality in all three dimensions. Spirocycles have been employed both as core structures and appended to the periphery of molecules in drug discovery. The major advantage that spiro cyclesoffer as core structures is their inherent three-dimensional nature and concomitant ability to project functionality in all three dimensions. However, to take full advantage of spirocycles, the ability to control stereochemistry at multiple positions...