Sharif Digital Repository

The growing global demographic and the growing rate of osteoporosis provide the definitive rationale for the development of effective methods for the treatment of osteoporotic defects of bone. These methods should not only compensate for ongoing injuries but should also manipulate the inherent disease processes to enhance the effectiveness of treatment. Therefore, the present study attempts to develop bioactive nanocomposite hydrogels through two different modalities—microgels and injectable bulk hydrogels—for the purpose of delivering alendronate (ALN) as a treatment approach for osteoporotic fractures. During the first phase of the research, gelatin-containing nanocomposite microgels...