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actinium-225
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Production and Quality Control of 225Ac-PSMA and Absorbed Dose Estimation of its in Different Human Organs
, M.Sc. Thesis Sharif University of Technology ; Hoseini, Abolfazl (Supervisor) ; Shirvani Arani, Simindokht (Supervisor) ; Zolghadri, Samaneh (Co-Supervisor)
Abstract
Prostate cancer is the second leading cause of cancer-related mortality in men after lung cancer. Prostate-specific membrane antigen (PSMA-617) labeled with Actinium-225 (225Ac) is currently being studied as a potential treatment for metastatic castration-resistant prostate cancer. This study aimed to produce the labeled compound [225Ac]Ac-PSMA-617 for the treatment of prostate cancer and its metastases. The compound was synthesized under optimized labeling conditions, and its radiochemical purity was determined to be over %96 using RTLC chromatography method. The biodistribution of the compound was evaluated in the tissues of healthy male mice, and the injected activity per unit mass of...