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Utilization of Macrocycles for the Preparation of a 3D-Printed Composite Scaffold with Drug Release Capabilities for Applications in Bone Tissue Engineering
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor)
Abstract
Given the growing trend of population aging, the prevalence of bone disorders such as osteoporosis is increasing. Accordingly, extensive efforts have been made in recent decades to design and develop efficient systems for treating this disease. Among the drugs used for osteoporosis therapy, bisphosphonates, particularly zoledronic acid have demonstrated superior efficacy. However, the drug concentration at the defect site is of critical importance; excessive local concentrations may negatively affect the viability of bone-forming cells. Therefore, designing a system that can inhibit osteoclast activity while preserving osteoblast viability is essential. In this project, to develop a suitable...
Improving U-shaped traps in a microfluidic chip to trap cancer cells to form spheroids using simulation
, Article 2024 31st National and 9th International Iranian Conference on Biomedical Engineering, ICBME 2024 ; 2024 , Pages 509-513 ; 979-833152971-0 (ISBN) ; Gholamshahi, F ; Saadatmand, M ; Sharif University of Technology
2024
Abstract
Microfluidic systems have made substantial progress over the last decade, finding numerous applications in various scientific fields, including biomedical engineering. These systems provide advanced methods for investigating the effects of anticancer drugs in in vitro environments, often referred to as organ-on-a-chip technology. Cancer spheroids, a type of cell aggregation, serve as the simplest 3D cancer model in laboratories, possessing histological and functional characteristics similar to tumor tissue. To form spheroids on a chip, cells must be trapped in suitable structures and allowed to grow and proliferate under appropriate conditions. Consequently, the design of these traps, with...
Improving the Energy Efficiency in Visible Light Communication
Networks with Space Division Multiplexing
,
M.Sc. Thesis
Sharif University of Technology
;
Salehi, Jawad
(Supervisor)
;
Beyranvand, Hamzeh
(Supervisor)
Abstract
Visible light communication networks provide wide bandwidth due to the use of visible light. In these networks, high efficiency can be achieved with proper system design and the use of space division multiplexing, effectively utilizing the existing bandwidth. Design issues in these networks are usually raised in the form of optimization. In this thesis, we optimize the energy efficiency of a visible light communication network with space division multiplexing in the transmitter by determining how to allocate LEDs to users and the amount of power for each LED. To accomplish this, we first propose two heuristic algorithms for determining how to allocate LEDs, and then we use a global...
Optimization of cellular lifi network deployment for gaussian mixture user distributions
, Article 9th Iran Workshop on Communication and Information Theory, IWCIT 2021, 19 May 2021 through 20 May 2021 ; 2021 ; 9781665400565 (ISBN) ; Beyranvand, H ; Zolala, E ; Salehi, J.A ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2021
Abstract
The long-term performance of LiFi networks significantly depends on the location of access points. The optimized placement can be determined based on the distribution of users in the room. In this paper, we investigate the placement optimization for average throughput maximization in the presence of asymmetric distributions. In particular, we represent users' distribution in the indoor environment by the Gaussian mixture model, which is powerful and computationally convenient. Then we obtain the optimized deployment for different scenarios using gradient ascent algorithm. The results show that optimization of deployment significantly improves the average throughput of the network. As the...
Synthesis Gd Ion-Based Contrast Agent for MRI Imaging of Musculoskeletal Trauma
, M.Sc. Thesis Sharif University of Technology ; Madaah Hosseini, Hamid Reza (Supervisor) ; Khachatourian, Adrineh (Supervisor)
Abstract
Given the importance of detecting damaged tissue following musculoskeletal trauma and preventing osteoarthritis, various imaging modalities are employed. Among these, magnetic resonance imaging (MRI) is particularly valuable due to its high efficacy and lack of ionizing radiation, additionally enabling molecular imaging. To enhance image resolution, contrast agents can be utilized, and through their surface modification, targeted imaging of damaged tissue can be achieved. Following joint trauma, the levels of the inflammatory cytokine IL-1β rise; therefore, designing a targeted contrast agent for this molecule is of great importance. In this study, a gadolinium-based contrast agent was...