Sharif Digital Repository

Given the growing trend of population aging, the prevalence of bone disorders such as osteoporosis is increasing. Accordingly, extensive efforts have been made in recent decades to design and develop efficient systems for treating this disease. Among the drugs used for osteoporosis therapy, bisphosphonates, particularly zoledronic acid have demonstrated superior efficacy. However, the drug concentration at the defect site is of critical importance; excessive local concentrations may negatively affect the viability of bone-forming cells. Therefore, designing a system that can inhibit osteoclast activity while preserving osteoblast viability is essential. In this project, to develop a suitable... 

Due to safety critical applications of the embedded systems, reliability is one of the most important properties of these systems. Wireless networks also have error prone data transmission channels and limited power consumption. Therefore reliability and power conservation are two vital characteristics of the wireless network especially in embedded applications. Since achieving to a desirable level of data reliability is power consuming, we must consider a trade-off between power consumption and data reliability. In wireless networks power consumption can be categorized into: power consumption in wireless devices and power consumption in data transmission. For decrement of wireless devices... 

In recent years, there has been a trend toward outsourcing data to the cloud provider. These companies must tackle the data security challenges. Generally these parties are assumed to be honest but curious. In past years, the research communities have been investigating different solution to ensure confidentiality.
In addition to data confidentiality access and pattern confidentiality is a high-priority issue in some cases so. potential adversary should be unable to drive information from the observed access pattern to the outsourced data. Despite the fact that there are more investigation in the field of data confidentiality, concern over data security are the rise in outsourcing data,... 

Visible light communication networks provide wide bandwidth due to the use of visible light. In these networks, high efficiency can be achieved with proper system design and the use of space division multiplexing, effectively utilizing the existing bandwidth. Design issues in these networks are usually raised in the form of optimization. In this thesis, we optimize the energy efficiency of a visible light communication network with space division multiplexing in the transmitter by determining how to allocate LEDs to users and the amount of power for each LED. To accomplish this, we first propose two heuristic algorithms for determining how to allocate LEDs, and then we use a global... 

Given the importance of detecting damaged tissue following musculoskeletal trauma and preventing osteoarthritis, various imaging modalities are employed. Among these, magnetic resonance imaging (MRI) is particularly valuable due to its high efficacy and lack of ionizing radiation, additionally enabling molecular imaging. To enhance image resolution, contrast agents can be utilized, and through their surface modification, targeted imaging of damaged tissue can be achieved. Following joint trauma, the levels of the inflammatory cytokine IL-1β rise; therefore, designing a targeted contrast agent for this molecule is of great importance. In this study, a gadolinium-based contrast agent was... 

Hydroxyurea is an anticancer drug that is commonly used to treat chronic myeloid leukemia (white blood cell cancer in bone marrow), polycythemia vera (red blood cell cancer), sickle cell anemia, solid tumors, and in particular leukemia. In this research, in addition to analyzing all available methods for synthesis of hydroxyurea, the most economical method for synthesis of hydroxyurea which is Hantzsch method was chosen; then we synthesized hydroxyurea crystals using a precipitation or crystallization process. To do so, two hydroxylamine hydrochloride and potassium cyanate reactants have been used in the semi batch reactor. Since the reaction efficiency and purity of the synthesized...