Sharif Digital Repository

In recent years, the tendency to use biodegradable and biocompatible polymer nanoparticles for drug delivery applications has been increasing, the reason for this being the possibility of precise control of the drug release rate, ease of use, and no need for external Surgery after the release of the drug, increases the therapeutic efficiency of the drug and reduces the side effects with its precise transfer. In this research work, drug carrier nanocomposites were prepared from polylactic acid (PLA), polyethylene glycol (PEG) and hydroxyapatite (HAp) and for the controlled release of ciprofloxacin (CIP). It was used to treat bone infections. The drug loading efficiency for nano-carriers was... 

“Entrepreneurship ecosystem” is defined as the elements – individuals, organizations or institutions – apart from the individual entrepreneur that are conducive to, or inhibitive of, the choice of a person to become an entrepreneur, or the probabilities of his or her success following launch. Entrepreneurial businesses operate locally or regionally and are therefore subject to local or regional contextual influence. Moreover particularly in larger countries there can exist significant variation in industry structure and economic base across regions, emphasizing the importance of regional focus. Adopting appropriate policies at the regional level need to have a deep and accurate... 

Today, the pace of information generation, fast processing and instant decision-making is increasing. In this regard, one of the main needs in the field of data management and processing is stream data processing. Today's world needs new methods to deal with and analyze these data. Two of the most challenging aspects of data streams are (i) concept drift, i.e. evolution of data stream over time, which requires the ability to make timely decisions against the high speed of receiving new data; (ii) limited memory storage and the impracticality of using memory due to the large amount of data. Clustering is one of the common methods for processing data streams, without having basic knowledge... 

In present research work, methods of preparing ion exchange membranes, especially anion exchange membranes, were studied and chemical modification of polysulfone was chosen as a safe and economical method for preparing anion exchange membranes. The chloromethylated polysulfone was characterized by HNMR spectroscopy and functionalization degree was determined according to peak area integration. Membranes were produced by mixing and amination of the chloromethylated and normal polysulfone (40-100% wt). Morphology and chemical structure of membranes were investigated by SEM images and FTIR spectroscopy.The ionic conductivity, ion exchange capacity and water content of samples were measured. The... 

In this study, we explore the dynamics of the stock market using an agent-based simulation platform. Our approach involves creating a multi-strategy market where each agent considers both fundamental and technical factors when determining their strategy. The agents vary in their approach to these factors and the time interval they use for technical analysis. Our findings indicate that investing heavily in reducing the value–price gap was a successful strategy, even in markets where there were no trading forces to reduce this gap. Furthermore, our results remain consistent across various modifications to the simulation’s structure  

Although existing literature on organizational culture and its change process contains meaningful and rich theories but our studies show that there is no perfect and detailed framework on linking organizational culture change and corporate entrepreneurship culture. In addition to that, Gamification –defined as taking the game design elements into non-game contexts– is a fruitful and academically rich research area. Fortunately an idea proposed recently to explain a method for enhancements in organizational culture in general, and in corporate entrepreneurship culture in particularby Yavari and Jafarian based on using game mechanisms. In their paper "A Gamification-Based Method for Corporate... 

Low back pain is a common medical problem around the world afflicting 80% of the population some time in their life. Low back injury can result from a loss of torso stability. This investigation seeks to apply existing methods to new applications and to develop new methods to assess spinal stability during its dynamical activities. In this study, firstly, optimization method is utilized as an appropriate explanation of role of nervous system in controlling of spine movements. Spine which is a complex structure of vertebrae and cartilage has been modeled by a 3D inverted pendulum with a ball and socket joint at L5/S1 incorporated with 18 muscle fascicles. Planning of point-to-point spine... 

In the method treatment of thermobrachytherapy, the method of this project, simultaneously use of two processes of thermotherapy and brachytherapy is considered, which can be a more effective treatment for the destruction of tumor tissue. In thermotherapy, the temperature of the tissue is artificially raised to a temperature that leads to cell dysfunction resulting in cell death. In brachytherapy, the destruction of defective tissue is done by placing a source in the tissue. In the present project, we supposed to consider both mechanisms simultaneously for treatment at the same time. In this project, radioactive material 125I is used as a source of radiation emission for brachytherapy. In...