Sharif Digital Repository

On the afternoon of October 14, 2020, we serendipitously discovered a novel “valley-hill” structure on the surface of a Metal-Organic Framework (MOF) after mixing it with a solution of tangerine peel extract (L) in the laboratory. This unexpected observation led to the formation of channels within the MOF surface and significantly improved release performance, particularly with doxorubicin (DOX). The unique valley-hill morphology and the resultant channels facilitated exceptional DOX diffusion into the MOF's porosity. Building on this structure, we systematically engineered the A520 (aluminum fumarate) MOF using green chemistry methodologies in a dual-stage process, incorporating L as a... 

Advancements in material science and engineering, especially in the field of porous nanomaterials lead to new types of therapeutics and technologies. Among different types of porous nanomaterials, metal–organic frameworks (MOFs) have been considered the most promising inorganic nanomaterials due to their significant stability and ease of functionalization. To date, very limited research has been done on developing nanocomposites based on MOFs and MXenes. The current experiment has been performed to design a novel UiO-66 MOF and MXene nanocomposite, modified with Rosmarinus officinalis (RO) leaf extracts for co-delivery of doxorubicin (DOX)/clustered regularly interspaced short palindromic... 

Metal–organic frameworks (MOFs) have been widely used as porous nanomaterials for different applications ranging from industrial to biomedicals. An unpredictable one-pot method is introduced to synthesize NH2-MIL-53 assisted by high-gravity in a greener media for the first time. Then, porphyrins were deployed to adorn the surface of MOF to increase the sensitivity of the prepared nanocomposite to the genetic materials and in-situ cellular protein structures. The hydrogen bond formation between genetic domains and the porphyrin’ nitrogen as well as the surface hydroxyl groups is equally probable and could be considered a milestone in chemical physics and physical chemistry for biomedical... 

The simple, effective and highly sensitive detection of hydrogen peroxide (H2O2), which belongs to the reactive oxygen species (ROS), at low concentrations plays an indispensable role in the field of environmental protection, biological research and safety. In this study, a dual-mode optical biosensor, UiO-66@OPD, was developed based on the inherent peroxidase mimicking activity of UiO-66 (Zr) and the optical reaction of ortho-phenylenediamine (OPD) by extending the π-system through oxidative coupling, prototropism and elimination to form OPDox, thereby exhibiting strong orangish absorbance and greenish fluorescence. The catalase-mimicking activity of UiO-66 (Zr) was demonstrated by the... 

Tissue engineering and regenerative medicine have solved numerous problems related to the repair and regeneration of damaged organs and tissues arising from aging, illnesses, and injuries. Nanotechnology has further aided tissue regeneration science and has provided outstanding opportunities to help disease diagnosis as well as treat damaged tissues. Based on the most recent findings, magnetic nanostructures (MNSs), in particular, have emerged as promising materials for detecting, directing, and supporting tissue regeneration. There have been many reports concerning the role of these nano-building blocks in the regeneration of both soft and hard tissues, but the subject has not been... 

Learning a foreign language encompasses a process of trial and error that can lead to the progression of the learner's interlanguage, meaning that the learners make use of their language knowledge that receives feedback and brings about progress through diagnosis of the problems and being corrected by the teacher. Therefore, there exists a need to analyze the underlying reasons causing the students to remain taciturn with a low willingness to communicate (WTC) during a language class. There has been much work done investigating the role of the learner's stable personal characteristics (traits) along with their situational changes at a specific time (states) that influence the student's... 

Accurate system identification (SI) is essential for flight controller design of unmanned aerial vehicles and microaerial vehicles (MAVs). SI can be performed either in frequency or time domain using flight test data. As flight testing is often costly and may even lead to catastrophic events before some flight stability analysis is at hand, a low-cost 5 degree-of-freedom free motion platform (FMP) is designed and used for initial identification of MAVs via wind tunnel testing. A typical MAV is constructed as a test case and equipped with inertial sensors for testing and validation purposes. The proposed FMP allows for both rotational as well as translational motions that in turn provide for... 

Using 3-D scanned data to analyze and extract pore network plays a vital role in investigation of porous media's characteristics. In this paper, a new simple method is developed to detect pores and throats for analyzing the connectivity and permeability of the network. This automated method utilizes some of the common and well-known image processing functions which are widely accessible by researchers and this has led to an easy algorithm implementation. In this method, after polishing and quality control of images, using city-block distance function and watershed segmentation algorithm, pores and throats are detected and 3-D network is produced. This method can also be applied on 2-D images... 

In this paper, we try to recognize and distinguish different groups of arrhythmia using novel features which have been obtained from the heart rate's phase space in recent years. For this purpose, we used Triangular Phase Space Mapping (TPSM) and Parabolic Phase Space Mapping (PPSM). For recognition, we used three groups of 15 subjects using the Physionet database (Arrhythmia, Congestive Heart Failure (CHF), and Atrial Fibrillation (AF)) with Normal Sinus Rhythm (NSR). The obtained features discriminate arrhythmia from NSR by p