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sharifpour--hanieh
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Lithography-directed Self-assembly for Designing Drug Particles of Various Sizes and Morphologies
, M.Sc. Thesis Sharif University of Technology ; Safari, Hanieh (Supervisor)
Abstract
To design a drug delivery system, the drug must be encapsulated within a carrier matrix. One of the main challenges in this field is encapsulating high drug doses while achieving a linear release profile at the target site to maintain drug concentration for optimal therapeutic effects. Consequently, many research groups have focused on refining fabrication techniques to maximize loading efficiency and optimize drug release profiles from delivery systems. A potential approach to addressing this issue is the direct fabrication of a controlled-release system from the active pharmaceutical ingredient (API) itself, eliminating the need for a carrier matrix. Studies have demonstrated that such...
Investigation on the Effect of Product Involvement in Online Targeted Advertising
, M.Sc. Thesis Sharif University of Technology ; Aslani, Shirin (Supervisor)
Abstract
Nowadays, one of the most popular methods of advertising is online advertising, which is commonly used by many businesses. In the meantime, targeting the right person at the right moment to show an advertisement is always a major concern of advertisers and other players in this field. One of the areas of study in the literature in this field is the investigation of factors affecting the effectiveness of targeted advertising. The purpose of the upcoming research is to investigate the impact of the advertised product involvement in targeted online advertising. This level of effectiveness is measured by considering click intention as a measure of effectiveness and examining the impact of...
Design and Synthesis of Electroactive Nanomaterials with Superior Energy Storage Capability based on Ion-Selective Structure for Ion-Selective Removal and their Application in Hybrid Capacitive Deionization
, Ph.D. Dissertation Sharif University of Technology ; Shahrokhian, Saeed (Supervisor)
Abstract
The existence of safe and sufficient water is of paramount importance for life on Earth and the survival of humankind. Although two-thirds of the Earth's surface is covered with water, the current demand for fresh water has not been met through these readily available sources for various reasons, including the salinity and hardness of surface waters. In the meantime, the continuous growth of the human population and emerging needs in industry and agriculture have increasingly raised the demand for water resources. Accessible freshwater resources such as rivers, groundwater, and lakes account for only a small portion of the total freshwater reserve. Therefore, today, desalination and...
Unraveling the ion uptake capacitive deionization of sea- and highly saline-water by sulfur and nitrogen co-doped porous carbon modified with molybdenum sulfide
, Article ACS Applied Materials and Interfaces ; Volume 15, Issue 36 , 2023 , Pages 42568-42584 ; 19448244 (ISSN) ; Hekmat, F ; Shahrokhian, S ; Sharif University of Technology
American Chemical Society
2023
Abstract
In parallel to the depletion of potable water reservoirs, novel technologies have been developed for seawater softening, as it is the most abundant source for generating deionized water. Although salt removal at subosmotic pressures and ambient temperatures by applying low-operating potentials with high energy efficiency made capacitive deionization (CDI) an advantageous water-softening process, its practical application is limited by insufficient ion removal capacity and low concentration influent. The performance of a CDI system is in progress with engineering the electrode active materials, also facilitating the advance design in highly saline- and seawater study. Herein, an innovative...
Impact of the Shape of the Loaded Particles on the Mechanical Properties of the Scaffolds and their Interaction with Macrophages
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Safari, Hanieh (Supervisor)
Abstract
Osteoarthritis is a common musculoskeletal disorder and the most prevalent form of arthritis. To date, no comprehensive cure has been reported for osteoarthritis, and its clinical management remains challenging. The primary therapeutic goals in the early stages of osteoarthritis are to increase joint mobility and control disease progression by continuously releasing drugs and molecules modulating inflammatory responses and reducing pain. Smart drug delivery platforms are one of the strategies to overcome the challenges of injectable and oral medications. Additionally, drug carrier particles can have different therapeutic targets based on their size and shape. Different therapeutic...
On the importance of gel rigidity and coverage in a smart water shutoff treatment in gas wells
, Article Journal of Natural Gas Science and Engineering ; Volume 31 , 2016 , Pages 808-818 ; 18755100 (ISSN) ; Escrochi, M ; Riazi, M ; Ayatollahi, S ; Sharif University of Technology
2016
Abstract
This paper addresses a conceptual study on different aspects of a novel smart treatment method for a relatively new challenge of saline water production from low permeability lenses of high flow gas wells. Selective sealing of such lenses along with minor effect on gas productivity usually faces practical difficulties due to the inherent permeability contrast. Engineered application of salt sensitive gellan biopolymer through a smart treatment scenario that includes a protective gas flow proved its ability for treating such challenge. This paper investigates the importance of the gel rigidity and its coverage in the smart treatment scenario through considering the brine salinity and the...
Towards an advanced electrochemical horizon: ion selectivity and energy harnessing through hybrid capacitive deionization with carbon-coated NaTi2(PO4)3 and N-rich carbon nests
, Article Journal of Materials Chemistry A ; Volume 12, Issue 45 , 2024 , Pages 31329-31346 ; 20507488 (ISSN) ; Hekmat, F ; Shahrokhian, S ; Pan, L ; Sharif University of Technology
2024
Abstract
For both water softening and energy storage, to date, a variety of capacitive devices have been developed; however, their dual functionality has been rarely investigated. An enhanced selective sodium-ion removal along with charge-storage was achieved by combining sodium-ion capture and release through sorption and regeneration steps of a capacitive deionization (CDI) process, respectively. Leveraging their unique and reversible Na+-removal capability, sodium superionic conductors (NASICONs) hold immense promise for hybrid capacitive deionization (HCDI). Despite the great desalination ability of HCDI systems, the unbalanced ion-capture and the possibility of co-ion expulsion have led to a...
Pinch Analysis of Heat Exchanger Networks in the Crude Oil Distillation Unit of Bandar-Abbas Refinery
, M.Sc. Thesis Sharif University of Technology ; Sadrhosseini, Hanieh (Supervisor) ; Shafii, Mohammad Behshad (Supervisor)
Abstract
Since oil prices continue to increase, energy conservation remains the prime industrial concern. Existing processes in power plants and oil refineries are not energy efficient as they should be therefore new projects can be defined to increase the energy efficiency without incurring any cost. The most appropriate utility for the processes should be explored to reduce emissions, increase the plant capacities and improve product qualities and energy efficiencies by one coherent strategic plan for the overall site which can be achieved by a full understanding of pinch technology and awareness of the available tools for applying it in practical way. Since the distillation unit of crude oil...
The Optimization of Self-Assembled Coacervate Drug Delivery Systems to Enhance Uptake by Macrophages and Their Polarization Towards an Anti-Inflammatory Phenotype
, M.Sc. Thesis Sharif University of Technology ; Safari, Hanieh (Supervisor) ; Mashayekhan, Shohreh (Supervisor)
Abstract
Macrophages play a crucial role in the healing process of chronic wounds in diabetic patients. These cells polarize from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, guiding the initial inflammation toward tissue repair and regeneration. In diabetic patients, physiological disturbances impair this polarization, resulting in persistent, chronic, and inflamed wounds. Glucocorticoid anti-inflammatory drugs are commonly used but have serious side effects, necessitating targeted delivery systems. This study aims to design and optimize self-assembled complex coacervate drug delivery system composed of gelatin and sodium alginate (GA/SA CCA) that can selectively uptake by...
Evaluating the Effect of Using a Customized Logistics Service on Sellers' Performance in Online Marketplace
, M.Sc. Thesis Sharif University of Technology ; Sepehri, Mehran (Supervisor) ; Khalili Nasr, Arash (Supervisor)
Abstract
The prosperity of online marketplaces depends on their ability to attract and keep sellers besides customers. Due to the lack of research in evaluating the role of sellers in this business model, the study tries to fill this gap through examining the effect of logistics capability on sellers' performance in an online marketplace. Specifically, a research model is developed to evaluate the effect of a customized logistics service, provided by the intermediary, on sellers' performance in the marketplace. In addition, the indirect effect of logistics capability as a mediator is examined on the previous causal link. Strong empirical support for the research model is provided by data from 1546...
Analysis of resistance spot welding process parameters effect on the weld quality of three-steel sheets used in automotive industry: Experimental and finite element simulation
, Article International Journal of Engineering, Transactions A: Basics ; Volume 33, Issue 1 , 2020 , Pages 148-157 ; Reza Kashyzadeh, K ; Minaei, M ; Sharifpour, A ; Riazi, S ; Sharif University of Technology
Materials and Energy Research Center
2020
Abstract
In the present research, the effects of spot-welding process parameters on the nugget diameter and electrode penetration depth of spot-welded joints were investigated. To achieve this, a spot-welded joint of three-thin sheet low carbon steels (same thicknesses of 0.8 mm) was simulated as an electerical-thermal-mechanical coupling of 3D finite element model. After validating the finite element simulation presented in this study by comparison with the experimental results for the spot diameter, various cases of spot welds were analyzed based on the design on experiment (i.e., Taguchi method). Six variables including electrode force, electric current, and quadrilateral times (squeeze, up-slope,...
Synthesis of Graphene Quantum Dots for Biomedical Application
, M.Sc. Thesis Sharif University of Technology ; Sadrnezhaad, KHatiboleslam (Supervisor) ; Ahhadiaan, Mohammad Mehdi (Co-Advisor)
Abstract
Graphene quantum dots (GQDs) as a sort of carbon-based nanomaterials are applied in a multitude of exciting areas. They are effective fluorescent probe for many potential biological and medical applications. In comparison to conventional organic fluorescent probes (organic dyes), GQDs have substantial advantages, such as photostability, excellent solubility, low cytotoxicity and biocompatibility.
In this thesis, green fluorescent GQDs have been prepared via solvothermal method from graphite powder.Various analysis methods were utilized to characterization of the product. So, several experiments on GQDs in solution and in solid substrate at room temperature have been performed. The...
In this thesis, green fluorescent GQDs have been prepared via solvothermal method from graphite powder.Various analysis methods were utilized to characterization of the product. So, several experiments on GQDs in solution and in solid substrate at room temperature have been performed. The...
Conference room reverberation time correction using helmholtz resonators lined with absorbers
, Article Shock and Vibration ; Vol. 2014, issue , May , 2014 ; Ghiasi, S. M. A ; Ghaffari, S. M ; Ramezanghorbani, F ; Sharifpour, S ; Irajizad, P ; Ghoreishi Langroudi, S. D ; Amjadi, A ; Sharif University of Technology
2014
Abstract
Echo and sound resonance in a conference room cause obscure speech and make listeners tired. Thus, the acoustical properties of a conference room are vitally important. The conference room 412 at Sharif University Physics Department failed to meet basic acoustical standards. The aim of this research is to improve reverberation time (RT) of the conference room using Helmholtz resonators with defined dimensions, diffusers, and sound absorbers. Helmholtz resonators are widely used to absorb sound noise especially at low frequencies. They are particularly useful when noise has a narrow-frequency band. One of the advantages of using Helmholtz resonators is their capacity to be tuned on different...