Sharif Digital Repository

Relative novelty and wide functionality of ionic liquids (ILs) have led to a surge in the studies devoted to experimental determination of their physicochemical properties. Systematic collection and analysis of the available data and development of predictive models to address the extreme diversity of IL systems are of great value in this regard. In the present work, the significance of speed of sound in ILs and their mixtures was outlined and related theoretical concepts were surveyed. A comprehensive database was utilized for the construction of predictive models based on least square support vector machine. By constructing four different models, the influence of temperature, molecular... 

Stimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular "gatekeepers" or "nanovalves." In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH,... 

Introduction: One of the biggest impacts that the nanotechnology has made on medicine and biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability in biological environments, poor uptake into cells and tissues, sub-optimal selectivity for targets and unwanted side effects. Nanocarriers can be designed as DDSs to overcome many of these drawbacks. One of the most versatile building blocks to prepare these nanocarriers is the ubiquitous, readily available and inexpensive protein, serum albumin. Areas covered: This review covers the use of different types of albumin (human, bovine, rat, and chicken egg) to prepare... 

Hand in hand with the flourish of the biodiesel industry, glycerol (GLY) as an inconvenient by-product has generated environmental and sustainability concerns. Devising measures for efficient transformation of GLY into value-added products is a promising solution. In this contribution, the transformation of GLY to lactic acid (LA) as a valuable chemical was investigated in a continuous process for industrial applications. In this regard, a catalytic method using heterogeneous Cu nanoparticles in NaOH solution was studied in a microreactor by a CFD simulation. A seven-inlet micromixer comprising an optimized mixing unit was incorporated for uniform distribution of the species. The effects of... 

For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes. Zein is a water-insoluble protein from maize; Gliadin is a 70% alcohol-soluble... 

This paper presents experimental results on the fatigue properties of Al-matrix nanocomposites prepared by the friction stir processing (FSP) technique. An Al-Mg alloy (AA5052) with different amounts (∼2 and 3.5 vol%) of pre-placed TiO2 nanoparticles were FSPed up to 6 passes to attain homogenous dispersion of nano-metric inclusions. Microstructural studies by electron microscopic and electron back scattering diffraction (EBSD) techniques showed that nano-metric Al3Ti (50 nm), TiO2 (30 nm), and MgO (50 nm) particles were distributed throughout a fine-grained Al matrix (<2 μm). Consequently, a significant improvement in the tensile strength and hardness was attained. Uniaxial... 

In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH-sensitive nanosystems represent promising smart delivery vehicles for transport and delivery of anticancer agents. Furthermore, pH-sensitive systems... 

According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally... 

The present research comes up with a novel DNA-loaded poly-L-lysine (PLL)/hyaluronan (HA) nanocarrier (DNA-loaded PLL/HA NCs) for gene delivery applications, as a promising candidate for gene delivery into diverse cells. A straightforward approach was employed to prepare such a nanosystem through masking DNA-loaded PLL molecules by HA. Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), field emission-scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) were used to analyse the interaction of the molecules as well as the physicochemical properties of the NCs. The NCs showed a negative charge of –24 ± 3 mV, with an average size of 138 ±... 

Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis.... 

In this paper, we describe a carbon dioxide mineralization process and its associated solid products. These solid products include amorphous silica, iron hydroxides and magnesium carbonates. These products were subjected to various characterization tests, and the results are published here. It was found that the iron hydroxides from this process can have different crystalline properties, and their formation depended very much on the pH of the reaction conditions. Different forms of magnesium carbonate were also obtained, and the type of carbonate precipitated was found to be dependent on the carbonation temperature. Hydromagnesite was obtained mainly at low temperatures, while dypingite was... 

Classic identifiability analysis of flow barriers in incompressible single-phase flow reveals that it is not possible to identify the location and permeability of low-permeability barriers from production data (wellbore pressures and rates), and that only averaged reservoir properties in between wells can be identified. We extend the classic analysis by including compressibility effects. We use two approaches: a twin experiment with synthetic production data for use with a time-domain parameter-estimation technique, and a transfer-function formalism in the form of bilaterally coupled four-ports allowing for an analysis in the frequency domain. We investigate the identifiability, from noisy... 

Demand response (DR) is known as a key solution in modern power systems and electricity markets for mitigating wind power uncertainties. However, effective incorporation of DR into power system operation scheduling needs knowledge of the price–elastic demand curve that relies on several factors such as estimation of a customer’s elasticity as well as their participation level in DR programs. To overcome this challenge, this paper proposes a novel autonomous DR scheme without prediction of the price–elastic demand curve so that the DR providers apply their selected load profiles ranked in the high priority to the independent system operator (ISO). The energy and reserve markets clearing... 

Personalized medicine is a new approach toward safer and even cheaper treatments with minimal side effects and toxicity. Planning a therapy based on individual properties causes an effective result in a patient’s treatment, especially in a complex disease such as cancer. The benefits of personalized medicine include not only early diagnosis with high accuracy but also a more appropriate and effective therapeutic approach based on the unique clinical, genetic, and epigenetic features and biomarker profiles of a specific patient’s disease. In order to achieve personalized cancer therapy, understanding cancer biology plays an important role. One of the crucial applications of personalized... 

Distant, dusty and extremely luminous galaxies form a key component of the high redshift universe, tracing the period of intense cosmic activity that ultimately gave rise to the present-day universe. These highly luminous galaxies, first detected in the ground-based submillimeter region, are however optically very faint, which hampers identification of the optical counterpart and the measurement of a redshift. We are developing a new direct-detection submm spectrograph DESHIMA. By taking advantage of the rapidly advancing technology of superconducting microresonators, DESHIMA will revolutionize the appearance and capabilities of a submm spectrograph. There will no longer be large grating... 

In the present study a finite difference method has been developed to model the transient fluid flow and heat transfer. A single fluid has been selected for modeling of mold filling and The SOLA-VOF 3D technique was modified to increase the accuracy of simulation of filling phenomena for shape castings. The model was then evaluated with the experimental methods. Refereeing to the experimental and simulation results a good consistency and the accuracy of the suggested model are confirmed. © 2005 Published by Elsevier B.V  

A new inelastic mechanism, detwinning-induced plasticity (DIP), is proposed to model the response of NiTi SMAs to cyclic loading, based on thermodynamic considerations. DIP is incorporated into a constitutive framework for NiTi SMA. The constitutive framework also includes well-established inelastic mechanisms of phase transformation, transformation-induced plasticity, residual martensite, and detwinning. The model is constructed at the single crystal scale using the framework of thermodynamics and a crystal plasticity formulation. An explicit scale-transition rule is adopted for the simulation of polycrystalline materials, allowing direct comparison of the model predictions with published...