Sharif Digital Repository

Wheat and flour are vital components of the food supply chain, and disruptions in their supply can have profound economic, social, and political impacts. This study focuses on optimizing the costs of the wheat and flour supply chain, encompassing production, imports, transportation, and shortages, while fostering economic and social development. A two-objective Mixed Integer Linear Programming (MILP) model is developed, integrating uncertainty through a two-stage stochastic programming approach based on scenarios. The augmented epsilon constraint method is utilized to address the bi-objective optimization problem. Key outcomes include identifying optimal locations for silo construction,... 

Accurate housing price prediction has long been a strategic issue in economic market analysis and urban decision-making. Due to the structural complexity of the housing market—characterized by hidden variables, incomplete data, and nonlinear relationships among influencing factors—traditional models often fail to provide sufficient accuracy. This study aims to design and evaluate a hierarchical machine learning framework to improve housing price prediction under the non-ideal data conditions of Iran’s market. In the first stage, latent or incomplete macroeconomic variables such as daily exchange rate and gold price were estimated using intermediate models, including the SARIMA algorithm. The... 

The pharmaceutical industry, as one of the most vital pillars of the healthcare system, plays a key role in improving quality of life. Rising global demand, coupled with threats such as natural disasters, pandemics, and shortages of raw materials, has highlighted the necessity of redesigning pharmaceutical supply chains with a resilience-oriented approach. This study proposes a multi-objective mathematical model for designing a pharmaceutical supply chain network that enhances system efficiency by minimizing costs, unmet demand, and delivery time. The model also accounts for drug perishability and defines disposal centers for the safe elimination of expired medicines. To address demand... 

In recent years, the popularity and applications of Non-Fungible Tokens (NFTs) have increased dramatically. For this reason, especially in the current decade, many researches have been conducted in different fields about the use of these tokens at the global level. One of the important and vital topics in the field of non-exchangeable tokens is the issues related to price prediction and the factors affecting their prices, which are mainly investigated using data analysis approaches. In this research, the factors affecting the price of non-exchangeable tokens of Bored Ape Yacht Club (BAYC) have been studied. These factors include traits, transaction data, rarity scores, transaction volume,... 

Today, demand function forecasting is one of the fundamental and critical challenges in organizational decision-making at both strategic and operational levels. Key decisions that significantly impact the success or failure of organizations -such as pricing, production planning, resource allocation, and market development- are directly influenced by the accuracy of demand forecasting. Since the demand function is typically affected by multiple factors including price, quality, economic conditions, social factors, and other variables shaping customer behavior, precise estimation requires employing diverse and accurate methods. Various approaches have been proposed in the literature for demand... 

The location problem is one of the main topics at the strategic level. This problem is investigated along with many areas such as network design and path covering problems. Routing between source and destination nodes is done in such a way that maximizes traffic coverage and reduces costs as much as possible. Routing problems are considered in goods distribution areas and urban transit systems. Goods distribution from set of cross-docks can help to reduce costs and improve resource efficiency. So, this topic is considered in this research and a suitable model is proposed. Defining and developing of the road and rail transportation networks are main topics in urban traffic management which... 

Nowadays, advanced and inexpensive pre-clinical methods for investigating the effects of anti-cancer drugs are expanding. One of the latest three-dimensional laboratory modeling for evaluating the effects of drugs is the use of tumor-on-chip technology, which actually models the physiological system of the body through three-dimensional scaffolds, multicellular cultures, and shaped vascular systems. In this study, three-dimensional culture of cancer cells was performed in the form of spheroids. A chip of U-shaped microstructures with and without gaps was used to trap cells and form cancer spheroids. We simulated the simultaneous effect of drug and oxygen concentration distribution inside the... 

The importance of routers in information transfer among networks is critical. Thus, vulnerabilities and security deficiencies in routers and the related services like routing protocols can be destructive not only for some hosts, but also for the whole network. Hence, it is necessary that 1) vulnerabilities related to the routers and their services be evaluated and analyzed, and 2) the functional aspects of routers related to the vulnerabilities be formally modeled and analyzed. In this thesis, we present a method for the evaluation and the analysis of OSPF routing protocol from the security point of view. First, reported vulnerabilities on the OSPF are collected and evaluated by a... 

Due to the development of heat pipes in different industries and special characteristics of heat pipes, in this study, it has been tried using computational fluid dynamics (CFD) method to simulate a heat pipe heat exchanger that can be a replacement for the normal radiator. The experimental model of this heat exchanger has been tested at past studies and the numerical simulation of the heat exchanger will analyze at present study. The use of heat pipe in the car radiator has many advantages such as reducing fluid pressure drop through the heat exchanger, high reliability due to the particular structure of the heat exchanger (individual performance of each heat pipe) and improving heat... 

Modeling and performance evaluation of the real time distributed systems is a significant problem. Stochastic activity network is one of the high level models used for this purpose. This network is an extension of generalized stochastic Petri net which is more powerful and flexible than other Petri net extensions. Checking the satisfiability of properties such as performance, dependability and user's expected properties is considerable in these models. Thus, using the approaches and generating modeling and model checking tools with the mentioned purpose is attractive. A model checker automatically checks the correctness of the system behaviors as properties against the model by getting the... 

This study has focused on the important problem of landing on a planet as an important current and future space mission. In this regard, dynamics modeling and integrated state estimation and control problems have been investigated in different views. To this aim, first a novel concurrent representation for translational and rotational kinematics has been developed based on the extension of modified Rodrigues parameters to dual space. This parameter set, called dual modified Rodrigues parameters (DMRP), is then utilized to establish an integrated roto-translational dynamic. The proposed DMRP-based kinematics and dynamics have been verified via comparison to traditional methods of... 

Prevalent deployment of Distributed Energy Resources(DERs) in the demand side of electrical energy grids has several advantages such as greenhouse gases emission reduction, mitigation of power losses in the distribution grids and abatement of the dependency on the wholesale generation companies. At the same time, it paves the way for the advent of local interactive energy trading frameworks. In the following thesis, a distributed data-driven algorithm is developed for market-clearing in a community-based local energy market. The social welfare maximization is considered as the objective of the energy trading. The production and demand of electricity are the decision variables of sellers and... 

Understanding biological systems requires extensive knowledge of individual parameters, and to study the processes of cell differentiation and cell behavior, a suitable environment must be created with the physiological conditions of the human body. For this purpose, with the knowledge of microfluidics, a microenvironment can be provided to study the behavior of cells on a small scale. The use of bone tissue model microfluidic chips is an alternative and new method in which it is possible to study the behavior of cells to differentiate into bone and to examine the toxicity of drugs, which in itself can help in the effective and successful treatment of these cases show. Therefore, in this... 

The main topic of this research is the navigation and control of a free-flying satellite with a robot manipulator while transferring and placing cargo on a space station. After connecting the cargo module, astronauts and robots need to deliver the available loads to the desired modules in a space station. Capturing an object or cargo is a critical issue studied extensively so far. However, delivery and placing of the cargo at the target point have not been investigated yet, to the best of the author’s knowledge; hence, this is a primary motivation for conducting the proposed research. After capturing the payload, the position and attitude of the manipulator with respect to the station’s... 

Cardiovascular disease (CVD) currently remains a considerable challenge for clinical treatments. CVDs account for N17.5 million deaths per year and will predictably increase to 23.6 million by 2030. The main purpose is to create human model systems to study the effect of disease mutations or drug treatment on the heart. In addition, engineered cardiac tissues are considered promising candidates to be transplanted to improve the function of diseased hearts. For engineered active tissues/organs, 3D bioprinting can fabricate complex tissue architecture with a spatiotemporal distribution of bioactive substances (cells, growth factors, and others) to better guide tissue regeneration. However,... 

Accurate and fast attitude estimation of a rigid body plays an essential role in the performance of a vehicle’s control system, especially aerospace vehicles. Ample works have been done to increase the accuracy and speed of the attitude estimation process, but all have been developed according to a model-based approach. This approach assumes that the torques acting on the body have a known dynamical model that is used for the attitude estimation. The purpose of the present research is to estimate the attitude via a model-free approach, i. e. dynamics of the torques acting on the body are no longer assumed to be known, and its learning is the next step. Thus, the problem formulation of this...