Sharif Digital Repository

This review aims to propose the integrative implementation of microfluidic devices, biomaterials, and computational methods that can lead to a significant progress in tissue engineering and regenerative medicine researches. Simultaneous implementation of multiple techniques can be very helpful in addressing biological processes. Providing controllable biochemical and biomechanical cues within artificial extracellular matrix similar to in vivo conditions is crucial in tissue engineering and regenerative medicine researches. Microfluidic devices provide precise spatial and temporal control over cell microenvironment. Moreover, generation of accurate and controllable spatial and temporal... 

Body posture measurement approaches, required in biomechanical models to assess risk of musculoskeletal injuries, are usually costly and/or impractical for use in real workplaces. Therefore, we recently developed three artificial neural networks (ANNs), based on measured posture data on several individuals, to predict whole body 3D posture (coordinates of 15 markers located on body's main joints), segmental orientations (Euler angles of 14 body segments), and lumbosacral (L5-S1) moments during static manual material handling (MMH) activities (ANNPosture, ANNAngle, and ANNMoment, respectively). These ANNs require worker's body height, body weight (only for ANNMoment), hand-load 3D position,... 

Machine-learning based human posture-prediction tools can potentially be robust alternatives to motion capture measurements. Existing posture-prediction approaches are confined to two-handed load-handling activities performed at heights below 120 cm from the floor and to predicting a limited number of body-joint coordinates/angles. Moreover, the extrapolating power of these tools beyond the range of the input dataset they were trained for (e.g., for underweight, overweight, or left-handed individuals) has not been investigated. In this study, we trained/validated/tested two posture-prediction (for full-body joint coordinates and angles) artificial neural networks (ANNs) using both... 

The main goal of this study is to investigate the effects of plaque structure on its stress distribution. Rupture of plaque causes cerebrovascular diseases which lead to high mortality rates all over the world. Computers are powerful tools to understand the mechanism of plaque rupture. In this study, 3D fluid structure interaction simulation is constructed in ABAQUS 6.13 to clarify the relation between stress distribution of plaque and its structure. A model of common carotid artery with distributed stenosis was chosen for the simulation. To investigate the effects of plaque structure on stress distribution, thickness of fibrous cap and lipid core size were varied in the stenosis.... 

Bone And Site Hold Tendon Inside (BASHTI) implant-less technique is proposed as an alternative to conventional tendon repair methods. This study aims to evaluate the strength of this technique under biceps loading conditions with different xation strategies. Twelve specimens with bovine tendons and Sawbones were constructed using two different insertion methods; in Group 1, 4 samples were prepared using a hand-hammer with a hitting frequency of 300 Beats Per Minute (BPM), while Group 2 included eight specimens with insertion using an auto-hammer applying a frequency of 3600 BPM. Both of the groups were tested under cyclic loading, followed by a pull-out until the failure. All the samples... 

This study aimed to investigate the influence of processing parameters on the mechanical properties of auxetic polyurethane foams including Poisson’s ratio and Young’s modulus. 12 different processing scenarios were considered using the method of Plackett–Burman in the design of experiments with three replicates for each one. Eventually, 36 foams were prepared with different densities and initial thicknesses, heating temperatures and times, applied compression ratios, and the rest times between two heating steps. The microstructures of the conventional and auxetic samples were observed by scanning electron microscopy (SEM). All samples were subjected to tensile loading in one direction with... 

Breast cancer is one of the most common fatal diseases in women. Early detection of malignant breast cancer could be a great help in treating this cancer. Many studies have been performed in order to detect the malignant of cancer tumor till now. It has been tried to contribute more in accurate diagnosis of breast cancer by Support Vector Machine, in this paper. LS and SMO methods have been utilized instead of conventional learning method of QP in SVM in this probe. The feasibility of 100 percent in sensitivity for LS-SVM, and 100 percent in specificity for SMO-SVM has been achieved in this assay by the proposed method, which this percentage has not been achieved so far in the previous... 

Conductive self -electrical stimuli bioactive scaffolds could be used the potential for peripheral nerve regeneration with the maximum efficiency. To produce such conductive self-electrical stimuli bioactive scaffolds, chopped spun piezoelectric nanofibers of polyvinylidene fluoride/mesoporous silica nanoparticle (PVDF/MCM41) are prepared and incorporated in gellan/polyaniline/graphene (gellan/PAG) nanocomposites which have been previously prepared by incorporation of polyaniline/graphene (PAG) nanoparticles in gellan gel at 80 °C. Highly conductive binary doped polyaniline/graphene nanoparticles are prepared by chemical oxidative polymerization of aniline monomer using in-suite... 

Full-body and lower-extremity human musculoskeletal models require feet ground reaction forces (GRFs) and centers of pressure (CoPs) as inputs to predict muscle forces and joint loads. GRFs/CoPs are traditionally measured via floor-mounted forceplates that are usually restricted to research laboratories thus limiting their applicability in real occupational and clinical setups. Alternatively, GRFs/CoPs can be estimated via inverse dynamic approaches as also implemented in the Anybody Modeling System (AnyBody Technology, Aalborg, Denmark). The accuracy of Anybody in estimating GRFs/CoPs during load-handling/reaching activities and the effect of its prediction errors on model-estimated spinal... 

Gel-fiber structure with the potential of extracellular matrix (ECM) mimics can be introduced as a suitable candidate for bioengineering applications. In this study, piezoelectric gellan gel-fiber was prepared with incorporating poly(vinylidenefluoride) (PVDF)/glass-flake in the gellan matrix. Glass-flake nanoparticles were modified with silane group, PVDF/glass-flake nanofibers were synthesized and short-strand nanofibers were fabricated using the mechanical homogenizer method. Brunauer–Emmett–Teller (BET), Fourier-transform infrared spectroscopy (FTIR), and Thermogravimetric analysis (TGA) analyses were used for surface modification study, and scanning electron microscopy (SEM),... 

Conductive self -electrical stimuli bioactive scaffolds could be used the potential for peripheral nerve regeneration with the maximum efficiency. To produce such conductive self-electrical stimuli bioactive scaffolds, chopped spun piezoelectric nanofibers of polyvinylidene fluoride/mesoporous silica nanoparticle (PVDF/MCM41) are prepared and incorporated in gellan/polyaniline/graphene (gellan/PAG) nanocomposites which have been previously prepared by incorporation of polyaniline/graphene (PAG) nanoparticles in gellan gel at 80 °C. Highly conductive binary doped polyaniline/graphene nanoparticles are prepared by chemical oxidative polymerization of aniline monomer using in-suite... 

Gel-fiber structure with the potential of extracellular matrix (ECM) mimics can be introduced as a suitable candidate for bioengineering applications. In this study, piezoelectric gellan gel-fiber was prepared with incorporating poly(vinylidenefluoride) (PVDF)/glass-flake in the gellan matrix. Glass-flake nanoparticles were modified with silane group, PVDF/glass-flake nanofibers were synthesized and short-strand nanofibers were fabricated using the mechanical homogenizer method. Brunauer–Emmett–Teller (BET), Fourier-transform infrared spectroscopy (FTIR), and Thermogravimetric analysis (TGA) analyses were used for surface modification study, and scanning electron microscopy (SEM),... 

In the present paper, the use of a carbon paste electrode modified by 2,2′-[1,2 buthanediylbis (nitriloethylidyne)]-bis-hydroquinone (BH) and TiO2 nanoparticles prepared by a simple and rapid method was described. The modified electrode showed an excellent character for electrocatalytic oxidization of norepinephrine (NE), acetaminophene (AC) and folic acid (FA). Using differential pulse voltammetry (DPV), a highly selective and simultaneous determination of NE, AC and FA has been explored at the modified electrode. Differential pulse voltammetry (DPV) peak currents of NE, AC and FA increased linearly with their concentration at the ranges of 4.0-1100.0 μM, 12.5-500.0 μM and 200.0-3200.0 μM,... 

The goal of this study is to investigate the effects of tendon and cannulated drill bit diameter on the strength of the bone and site hold tendon inside (BASHTI) fixation technique for an anterior cruciate ligament (ACL) reconstruction. Bovine digital tendons and Sawbones blocks were used to mimic the ACL reconstruction. Mechanical strength of the specimens was measured using a cyclic loading continued by a single cycle pullout load until failure to simulate the real postsurgical loading conditions. Finally, failure modes of specimens and ultimate failure load were recorded. The maximum possible tendon surface strain (i.e., tendon compression [TC]) for tendon diameters of 6, 7, 8, and 9 mm... 

Background: Bone and Site Hold Tendon Inside (BASHTI) technique is an organic implant-less technique for anterior cruciate ligament (ACL) reconstruction with some clinical advantages, such as speeding up the healing process, over implantable techniques. The study aims to compare the mechanical properties of BASHTI technique with the conventional interference screw technique. Methods: To investigate the mechanical properties, 20 in-vitro experimental tests were conducted. Synthetic dummy bone, along with fresh digital bovine tendons, as a graft, were used for experiments. Three loading steps were applied to all specimens, including a preconditioning, a main cyclic, and a pull-out loading.... 

The goal of this study is to investigate the effects of tendon and cannulated drill bit diameter on the strength of the bone and site hold tendon inside (BASHTI) fixation technique for an anterior cruciate ligament (ACL) reconstruction. Bovine digital tendons and Sawbones blocks were used to mimic the ACL reconstruction. Mechanical strength of the specimens was measured using a cyclic loading continued by a single cycle pullout load until failure to simulate the real postsurgical loading conditions. Finally, failure modes of specimens and ultimate failure load were recorded. The maximum possible tendon surface strain (i.e., tendon compression [TC]) for tendon diameters of 6, 7, 8, and 9 mm... 

Background: BASHTI is an implant-less anterior cruciate ligament (ACL) reconstruction technique, which resolves the problems caused by implants such as interference screws. This study aims to investigate the effect of the drill bit and tendon’s diameter on the Core Bone Engaged Length (CBEL) and the fixation strength. CBEL is the length of core bone which has a full engagement with both tunnel and graft at the same time. Methods: 60 in-vitro tests were conducted for 6, 7, 8, and 9 mm tendon sizes with a 10 mm bone tunnel. In this study bovine tendons and dummy bone blocks were used to model the fixation. Drill bits were used to extract the core bone for securing the auto-graft. A three-stage... 

Discriminative subspace analysis is a popular approach for a variety of applications. There is a growing interest in subspace learning techniques for face recognition. Principal component analysis (PCA) and eigenfaces are two important subspace analysis methods have been widely applied in a variety of areas. However, the excessive dimension of data space often causes the curse of dimensionality dilemma, expensive computational cost, and sometimes the singularity problem. In this paper, a new supervised discriminative subspace analysis is presented by encoding face image as a high order general tensor. As face space can be considered as a nonlinear submanifold embedded in the tensor space, a... 

In this paper, we introduce a new approach to fault detection and isolation for robot manipulators. Our technique is based on using a new simplified Euler-Lagrange (EL) equation that reduces complexity of the proposed fault detection method. The proposed approach isolates the faults and is capable of handling the uncertainty in manipulator gravity vector. It is shown that the effect of uncalibrated torque sensor measurement is asymptotically rejected in the detection process. A simulation example is presented to illustrate the results. © 2009 IEEE  

Cephalometric analysis has an important role in diagnosis and treatment of dental disharmonies. In this paper, we propose an efficient, fast, and automatic method to localize cephalometric landmarks on digitized x-ray images. The proposed algorithm uses the information of the marked landmarks on a reference normal cephalometry image as the prior knowledge. In the first step of the proposed method, the image is automatically divided into several regions and three main control points are located on it. These are then matched to their corresponding points on the reference image to form an affine transform matrix that describes how other points on the reference image should be mapped to the...