Sharif Digital Repository

Timoshenko beam model is widely exploited in the literature to examine the mechanical behavior of stubby beam-like components. Timoshenko beam theory is well-known to require the shear correction factor in order to recognize the non-uniform shear distribution at a section. While a variety of shear correction factors are appeared in the literature so far, there is still no consensus on the most appropriate form of the shear correction factor. The Saint-Venant's flexure problem is first revisited in the frame work of the classical theory of elasticity and a highly accurate approximate closed-form solution is presented employing the extended Kantorovich method. The resulted approximate solution... 

Practical vibration-based nano-devices are normally subject to disturbances where intense vibrations reveal significant nonlinear characteristics. Efficient implementation of nonlinear nano-systems requires comprehensive knowledge of the nonlinear dynamics. Nonlinear vibration characterization of elastic nano-bars with large vibration amplitudes is rigorously examined in the present study. The fascinating concept of simulating long-range interactions can be realized in the framework of the nonlocal elasticity theory, and thus, nano-scale effects are taken into account in the framework of the stress-driven nonlocal integral elasticity. The equivalent nonlocal differential condition equipped... 

Ciprofloxacin is an alternative to vancomycin for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The objective of this study was to optimization of niosomes encapsulated ciprofloxacin and evaluate their antibacterial and anti-biofilm efficacies against ciprofloxacin-resistant methicillin-resistant S. aureus (CR-MRSA) strains. Formulation of niosomes encapsulated ciprofloxacin were optimized by changing the proportions of Tween 60, Span 60, and cholesterol. The optimized ciprofloxacin encapsulated niosomal formulations based on Span 60 and Tween 60 were prepared and characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM) and... 

Background: There has been considerable interest in target immunotherapy in patients with diabetes. This study was designed to identify the effect of BCG vaccination in the treatment of Iranian patients with longstanding diabetes mellitus type 1. Methods: After approval of the cross-sectional study protocol by the ethics committee under number IRCT2017042919940N2, a total of 19 Iranian volunteers with diabetes mellitus type 1 completed this 48-month study. These patients received three 0.1 ml intradermal injections of BCG vaccination in weeks 0, 4 and 24. The serum level of glucose, HgbA1C and c-peptide was measured before and serially after the interventions. Insulin requirements were... 

In this study, in-silico properties of Gingerol (Gin) and Letrozole (Let), as two potential anti-cancer drugs, were investigated and some significant ADME drawbacks were predicted. Accordingly, to address the drawbacks, mesoporous silica nanoparticles (MSNs) were prepared, functionalized with zinc, amine, and graphene oxide (GO) (MZNG), and employed for loading and delivery of the both to breast cancer cells in-vitro. Biophysical analysis showed that Let and Gin-loaded MZNGs have spherical structure with a mean diameter of ∼210 nm. The MZNGs provided high entrapment efficiency of Let and Gin with a pH-sensitive sustained release profile. The cytotoxicity assay demonstrated that loading of... 

Micro motion stages are one of the essential components in field of micro robotics and ultra fine positioning systems. This research presents the optimum design of a 3-DOF micro motion stage and its position control using FEM simulation. This stage to be studied uses a 3 RRR flexure hinge base compliant mechanism driven by three piezoelectric stack actuators to provide micro scale planar motion. First of all parametric modeling of the stage will be fulfilled in ANSYS environment utilizing a commercial piezostack and different types of flexure hinges. Hence the Jacobian matrix will be achieved for each case. The optimum selection of the hinge form will be achieved upon results of the previous... 

The chaotic dynamics of roto-translatory motion of a triaxial Kelvin-type gyrostat satellite under gravity gradient perturbations is considered. The Hamiltonian approach is used for modelling of the coupled spin-orbit equations of motion. The complex Hamiltonian of the system is reduced via the extended Deprit canonical transformation using the Serret- Andoyer variables. Therefore, this reduction leads to the derivation of the perturbation form of the Hamiltonian that can be used in the Ricci curvature criterion based on the Riemannian manifold geometry for the analysis of chaos phenomenon. The results obtained from Ricci method as well as the values from the Lyapunov exponent demonstrate... 

IT Governance provides a business focus to enable alignment between business and IT objectives at high level COBIT framework and focused on IT operational levels, ITIL standard. COBIT and ITIL are not mutually exclusive and can be combined to provide a powerful IT governance, control and best-practice framework in IT service management. So ITIL business-IT strategic alignment perspective could be improved using COBIT framework. Focusing on COBIT processes which support (primarily and secondarily) strategic alignment, in this paper, first, we map COBIT 4.1 to ITIL v3 to identify how ITIL cover COBIT control objectives. Furthermore, based on control objectives which are not completely... 

Quasi-periodic and chaotic behavior, along with the control of chaos for a Gyrostat satellite (GS), is investigated in this work. The quaternion-based dynamical model of the GS is first derived, and then the influences of the reaction wheels in the GS structure, under the gravity gradient perturbation that causes a route to chaos through quasi-periodicity mechanism, is investigated. For the suppression of chaos in the system, a chaos control system with the quaternion feedback is designed for the GS based on the extension of the Ott-Grebogi-Yorke (OGY) method using the linearization of the Poincaré map. In the extended OGY controller, the Poincaré map is estimated using the Least Square... 

This article presents a study on the capability of the time domain OMA method, NExT-ERA, to identify closely spaced structural dynamic modes. A survey in the literature reveals that few experimental studies have been conducted on the effectiveness of the NExT-ERA methodology in case of closely spaced modes specifically. In this paper we present the formulation for NExT-ERA. This formulation is then implemented in an algorithm and a code, developed in house to identify the modal parameters of different systems using their generated time history data. Some numerical models are firstly investigated to validate the code. Two different case studies involving a plate with closely spaced modes and... 

Micro motion stages are one of the essential components in field of micro robotics and ultra fine positioning systems. This research presents the optimum design of a 3-DOF micro motion stage and its position control using FEM simulation. This stage to be studied uses a 3 RRR flexure hinge base compliant mechanism driven by three piezoelectric stack actuators to provide micro scale planar motion. First of all parametric modeling of the stage will be fulfilled in ANSYS environment utilizing a commercial piezostack and different types of flexure hinges. Hence the Jacobian matrix will be achieved for each case. The optimum selection of the hinge form will be achieved upon results of the previous... 

Accurate system identification (SI) is essential for flight controller design of unmanned aerial vehicles and microaerial vehicles (MAVs). SI can be performed either in frequency or time domain using flight test data. As flight testing is often costly and may even lead to catastrophic events before some flight stability analysis is at hand, a low-cost 5 degree-of-freedom free motion platform (FMP) is designed and used for initial identification of MAVs via wind tunnel testing. A typical MAV is constructed as a test case and equipped with inertial sensors for testing and validation purposes. The proposed FMP allows for both rotational as well as translational motions that in turn provide for... 

In the current study, niosome-encapsulated tobramycin based on Span 60 and Tween 60 was synthesized and its biological efficacies including anti-bacterial, anti-efflux, and anti-biofilm activities were investigated against multidrug resistant (MDR) clinical strains of Pseudomonas aeruginosa. The niosomal formulations were characterized using scanning electron microscopy, transmission electron microscopy, and dynamic light scattering measurement. The encapsulation efficiency was found to be 69.54% ±; 0.67. The prepared niosomal formulations had a high storage stability to 60 days with small changes in size and drug entrapment, which indicates that it is a suitable candidate for pharmaceutical... 

In the current study, niosome-encapsulated tobramycin based on Span 60 and Tween 60 was synthesized and its biological efficacies including anti-bacterial, anti-efflux, and anti-biofilm activities were investigated against multidrug resistant (MDR) clinical strains of Pseudomonas aeruginosa. The niosomal formulations were characterized using scanning electron microscopy, transmission electron microscopy, and dynamic light scattering measurement. The encapsulation efficiency was found to be 69.54% ±; 0.67. The prepared niosomal formulations had a high storage stability to 60 days with small changes in size and drug entrapment, which indicates that it is a suitable candidate for pharmaceutical... 

Vivid banding pattern of the chromosome image is a crucial part for diagnosis in karyotype medical test. Furthermore, thriving computer aided segmentation and classification depend on the initial image quality. In this paper, we propose an adaptive and iterative histogram matching algorithm for chromosome contrast enhancement especially in banding patterns which is one of the most important information laid in chromosome image. Objective histogram, with which the initial image needs to be matched, is created based on processes on the initial image histogram. Calculation of statistical moments of image histogram and determination of parameters in each step of iteration based on these moments... 

Vivid banding patterns in medical images of chromosomes are a vital feature for karyotyping and chromosome classification. The chromosome image quality may be degraded by many phenomenon such as staining, sample defectness and imaging conditions. Thus, an image enhancement processing algorithm is needed before classification of chromosomes. In this paper, we propose an adaptive and iterative histogram matching (AIHM) algorithm for chromosome contrast enhancement especially in banding patterns. The reference histogram, with which the initial image needs to be matched, is created based on some processes on the initial image histogram. Usage of raw information in the histogram of initial image... 

The present study tries to use the methanol-silver nanofluid filled thermosyphon heat exchanger and compares the effectiveness as well as energy saving with pure methanol. Experimental results show that using methanol-silver nanofluid, leads to energy saving around 8.8-31.5% for cooling and 18-100% for reheating the supply air stream in an air conditioning system  

Most of the publications regarding the maxim covering location problem (MCLP) address the case where the decision is to be made for one period. In this paper, we deal with a rather untouched version of MCLP which is called dynamic MCLP (DMCLP). In order to solve this problem, a simulated annealing (SA) has been presented. The proposed solution algorithm is capable of solving problems with up to 2500 demand nodes and 200 potential facilities with a fair amount of exactness. Our experiments showed that the proposed approach finds solutions with errors less than one percent  

In the present study, alginate/cartilage extracellular matrix (ECM)-based injectable hydrogel was developed incorporated with silk fibroin nanofibers (SFN) for cartilage tissue engineering. The in situ forming hydrogels were composed of different ionic crosslinked alginate concentrations with 1% w/v enzymatically crosslinked phenolized cartilage ECM, resulting in an interpenetrating polymer network (IPN). The response surface methodology (RSM) approach was applied to optimize IPN hydrogel's mechanical properties by varying alginate and SFN concentrations. The results demonstrated that upon increasing the alginate concentration, the compression modulus improved. The SFN concentration was...