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Design of robust control strategy in drug and virus scheduling in nonlinear process of chemovirotherapy
, Article Computers and Chemical Engineering ; Volume 150 , 2021 ; 00981354 (ISSN) ; Moradi, H ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
Since the injection of the oncolytic viruses in the virotherapy process reduces the toxicity and drug resistance inherent in the chemotherapy; chemovirotherapy as a novel combination therapy has become an efficient cancer treatment. The primary purpose of this paper is to design a robust optimal control strategy for the chemovirotherapy through which the tumor density decreases to its stable condition with limited drug and virus delivery. This desired treatment should be responsive in the presence of input disturbances and parametric uncertainties. In this regard, an ODE (Ordinary Differential Equation) mathematical model of the chemovirotherapy process presenting the connection between the...
Performance of a linear controller in the nonlinear model of drug and virus delivery in cancer chemovirotherapy: A comparison between continuous and discrete approaches
, Article Scientia Iranica ; Volume 30, Issue 3 B , 2023 , Pages 969-982 ; 10263098 (ISSN) ; Moradi, H ; Sharif University of Technology
Sharif University of Technology
2023
Abstract
Best cancer treatment is the one which reduces the tumor's density in minimum time with less side effects, considering the input limitations. In this paper, a tracking controller was designed to achieve the mentioned objectives, simultaneously. An ordinary differential equations (ODEs)-based mathematical model of a human's body under chemovirotherapy was selected, which includes the uninfected and infected tumor cells, free viruses, immune cells, and a chemotherapeutic drug. Stability analysis was used to determine the sensible equilibrium points. For tracking purposes, a servo controller based on the entire eigenstructure assignment (EESA) approach was applied to the model, continuously and...
Using Robust Control in Drug and Virus Scheduling in Chemovirotherapy Nonlinear Model
, M.Sc. Thesis Sharif University of Technology ; Moradi, Hamed (Supervisor)
Abstract
Best cancer treatment is the one which reduces the tumor density in minimum time and side effects, considering the input limitations. In this paper, tracking controller and robust controllers are designed to achieve the mentioned objectives, simultaneously. An ODE-based mathematical model of the human body under chemovirotherapy is selected, which includes the uninfected and infected tumor cells, free viruses, immune cells, and a chemotherapeutic drug. For tracking purposes, a servo controller based on the entire eigenstructure assignment (EESA) approach is applied to the model, continuously and discretely. For robust purposes H-infinity and D-K iteration approaches are implemented and...
Solvent Extraction of Indium from PlS Solution Produced of Zinc Concentrate Leaching
, M.Sc. Thesis Sharif University of Technology ; Yoozbashizadeh, Hossein (Supervisor)
Abstract
Indium is one of the most important metals in electronics and nuclear industry with increasing demand. The most important application of Indium is in the preparation of thin films containing this metal in LCD manufacturing, television, laptops, monitors and CD players. Indium is a rare metal and it has not original mineral. The most important source of it is zinc minerals and regularly obtained from processing by-products of this minerals. The main problem of production of Indium is the simultaneous presence iron ions in the solution of dissolved minerals of zinc. In this project, extraction of Indium from acidic pregnant leaching solution of roasted zinc concentrate contained at less than...
Prevention of gestational diabetes mellitus (GDM) and probiotics: Mechanism of action: A review
, Article Current Diabetes Reviews ; Volume 16, Issue 6 , 2020 , Pages 538-545 ; Bagheri, N ; Mohammad Alizadeh Charandabi, S ; Kashani, N ; Mobaraki Asl, N ; Mirghafurvand, M ; Asgharian, H ; Ansari, F ; Pourjafar, H ; Sharif University of Technology
Bentham Science Publishers
2020
Abstract
Background: Gestational Diabetes Mellitus (GDM) is a health problem that is increasing around the world. Introduction: Prevention of GDM, rather than treatment, could have several benefits in terms of both health and economic cost. Even a slight reduction in maternal glucose in non-diabetic women, particularly in women at high risk for GDM, may have significant benefits for pregnancy results and the future health of off-springs. Probiotics are a relatively new intervention, which are assessed by mothers’ metabolism, and can reduce blood sugar levels, prevent gestational diabetes and reduce the maternal and fetal complications resulting from it. The aim of this study was to review the studies...
Proton Path Tracking in Proton Computed Tomography using Machine Learning
, M.Sc. Thesis Sharif University of Technology ; Vosoughi, Naser (Supervisor) ; Riazi Mobaraki, Zafar (Supervisor) ; Alibeigi, Ehsan (Co-Supervisor)
Abstract
One of the main problems in proton computed tomography is the reduction of the spatial resolution of the image due to multiple Coulomb scattering of protons while passing through the material. Estimating the most likely path of protons inside the material can be beneficial to solve this problem. In this regard, artificial neural networks, as one of the innovative solutions in the field of machine learning, have helped to improve the accuracy of estimating the most likely path of protons. In this study, an artificial neural network with an adaptive moment estimation optimization algorithm was designed to estimate the most likely path of protons. The network was trained using data obtained...
Application of Multiscale methods for Modeling Spatial Heterogeneity in Complex Reservoirs
, M.Sc. Thesis Sharif University of Technology ; Farhadpour, Farhad A (Supervisor) ; Sayf Kordi, Ali Akbar (Supervisor)
Abstract
Underground reservoirs are highly complicated due to the presence of spatial heterogeneities at length scales that span from micrometer in pore structure of the rocks to kilometer in the reservoir models. While large-scale flow units need to be characterized using seismic and well data, detailed displacements of fluids in pore space need to be modeled using thin section analysis and pore network modeling. It is therefore necessary to adopt a multi-scale approach to reservoir description to make best use of all the available data that vary over several orders of magnitude, from micro-scale in pore structure to field scale in reservoir flow models. In this thesis, an integrated framework for...
Improvement in dye and lead removal efficiency of PES membranes by blending sulfur containing adsorbent nanomaterials
, Article Journal of Environmental Chemical Engineering ; Volume 12, Issue 5 , 2024 ; 22133437 (ISSN) ; Soylu, S ; Osman, D ; Tuncay, G ; Mobaraki, A ; Marjani, Z ; Ziyaei Halimehjani, A ; Koyuncu, I ; Sharif University of Technology
2024
Abstract
The study examines the synthesis and characterization of novel Fe3O4@SiO2@PrEDAS nanoparticles (NP) as a magnetic adsorbent and its application in polyethersulfone (PES) ultrafiltration (UF) membrane fabrication using the phase inversion method by adding it into the membrane dope solution at different concentrations. The efficiency of Fe3O4@SiO2@PrEDAS adsorbent was evaluated by batch adsorption of Pb(II). The performance of the modified membranes was investigated by determining the pure water flux (PWF), bovine serum albumin (BSA) rejection, Pb(II) removal, dye rejection, and antifouling characteristics. Considering the results, it was observed that the NP is an effective adsorbent for...
Probability of missed detection as a criterion for receiver placement in MIMO PCL
, Article IEEE National Radar Conference - Proceedings, 7 May 2012 through 11 May 2012, Atlanta, GA ; 2012 , Pages 0924-0927 ; 10975659 (ISSN) ; 9781467306584 (ISBN) ; Chitgarha, M. M ; Radmard, M ; Nayebi, M. M ; Sharif University of Technology
IEEE
2012
Abstract
Using multiple antennas at the transmit and receive sides of a passive radar brings both the benefits of MIMO radar and passive radar. However one of the obstacles arisen in such configuration is the receive antennas placement in proper positions so that the radar performance is improved. Here we just consider the case of positioning one receiver among multiple illuminators of opportunity. Indeed it is a start for the solution of optimizing the geometry of the multiple receivers in a passive radar
An efficient method for the ring opening of epoxides with aromatic amines by Sb(III) chloride under microwave irradiation
, Article Journal of Chemical Research ; Issue 4 , 2008 , Pages 220-221 ; 03082342 (ISSN) ; Hashemi, M. M ; Mottaghi, M. M ; Foroughi, M. M ; Sharif University of Technology
2008
Abstract
SbCl3 supported on montmorillonite K-10 is an efficient catalyst for the ring opening of epoxides with aromatic amines under solvent-free conditions and microwave irradiation to give the corresponding b-amino alcohols in high yields with high regioselectivity
Resource allocation for uav-enabled integrated sensing and communication (isac) via multi-objective optimization
, Article ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings ; Volume 2023-June , 2023 ; 15206149 (ISSN); 978-172816327-7 (ISBN) ; Naghsh, M. M ; Karbasi, M ; Nayebi, M. M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2023
Abstract
In this paper, we consider an integrated sensing and communication (ISAC) system with wireless power transfer (WPT) where an unmanned aerial vehicle (UAV)-based radar serves a group of energy-limited communication users in addition to its sensing functionality. In this architecture, the radar senses the environment in phase 1 (namely sensing phase) and mean-while, the communications users (nodes) harvest and store the energy from the radar transmit signal. The stored energy is then used for information transmission from the nodes to UAV in phase 2, i.e., uplink phase. Performance of the radar system depends on the transmit signal as well as the receive filter; the energy of the transmit...
MIMO radar signal design to improve the MIMO ambiguity function via maximizing its peak
, Article Signal Processing ; Volume 118 , 2016 , Pages 139-152 ; 01651684 (ISSN) ; Radmard, M ; Nazari Majd, M ; Karbasi, S. M ; Nayebi, M. M ; Sharif University of Technology
Elsevier
2016
Abstract
One of the important obstacles in MIMO (Multiple Input Multiple Output) radars is the issue of designing proper transmit signals. Indeed, the capability of signal design is a significant advantage in MIMO radars, through which, the system can achieve much better performance. Many different aspects of this performance improvement have been considered yet, and the transmit signals have been designed to attain such goal, e.g., getting higher SNR or better detector's performance at the receiver. However, an important tool for evaluating the radar's performance is its ambiguity function. In this paper, we consider the problem of transmit signal design, in order to optimize the ambiguity function...
Detection-localization tradeoff in MIMO radars
, Article Radioengineering ; Volume 26, Issue 2 , 2017 , Pages 581-587 ; 12102512 (ISSN) ; Radmard, M ; Chitgarha, M. M ; Bastani, M. H ; Nayebi, M. M ; Sharif University of Technology
2017
Abstract
Two gains play key roles in recently developed MIMO wireless communication systems: "spatial diversity" gain and "spatial multiplexing" gain. The diversity gain refers to the capability to decrease the error rate of the MIMO channel, while the multiplexing gain implicitly refers to the amount of increase in the capacity of the MIMO channel. It has been shown that there is a fundamental tradeoff between these two types of gains, meaning interplay between increasing reliability (via an increase in the diversity gain) and increasing data rate (via an increase in the multiplexing gain). On the other hand, recently, MIMO radars have attracted much attention for their superior ability to enhance...
Antenna placement and power allocation optimization in MIMO detection
, Article IEEE Transactions on Aerospace and Electronic Systems ; Vol. 50, Issue 2 , April , 2014 , pp. 1468-1478 ; Chitgarha, M. M ; Majd, M. N ; Nayebi, M. M ; Sharif University of Technology
2014
Abstract
It is a well known fact that using multiple antennas at transmit and receive sides improves the detection performance. However, in such multiple-input multiple-output (MIMO) configuration, proper positioning of transmitters and receivers is a big challenge that can have significant influence on the performance of the overall system. In addition, determining the power of each transmitter under a total power constraint is a problem that should be solved in order to enhance the performance and coverage of such a system. In this paper, we design the Neyman-Pearson detector under the Rayleigh scatter model and use it to introduce a criterion for the antenna placement at both transmit and receive...
Ambiguity function of MIMO radar with widely separated antennas
, Article Proceedings International Radar Symposium ; 16 -18 June , 2014 ; ISSN: 21555753 ; Chitgarha, M. M ; Nazari Majd, M ; Nayebi, M. M ; Sharif University of Technology
2014
Abstract
There has been much interest, recently, towards exploiting the Multiple-Input Multiple-Output (MIMO) technique in radar. It is shown that using multiple antennas at transmit and receive sides can improve the performance of the system. However, in order to analyze the system's performance, its ambiguity function, i.e. the ambiguity function of a MIMO radar, is needed to be defined. In this paper, beginning from the information theoretic definitions, we derive such function, specifically for a MIMO radar with widely separated antennas
Choosing the position of the receiver in a MISO passive radar system
, Article European Microwave Week 2012: "Space for Microwaves", EuMW 2012, Conference Proceedings - 9th European Radar Conference, EuRAD 2012 ; 2012 , Pages 318-321 ; 9782874870293 (ISBN) ; Majd, M. N ; Radmard, M ; Nayebi, M. M ; Sharif University of Technology
2012
Abstract
By combining the two ideas of MIMO (Multiple Input Multiple Output) and PCL (Passive Coherent Location) in radar, one can achieve the advantages of both recently developed techniques simultaneously. While using multiple antennas at the receive side provides a spatial diversity of the object to be detected, using multiple illuminators of opportunity, most importantly, makes the radar covert to the interceptors. One obstacle in such MIMO configuration is choosing the positions of the receive antennas. In this paper, after analyzing the Neyman-Pearson detector for the DVB-T based PCL, we introduce the probability of missed detection as a criterion to place the receive antenna. Here, we only...
Adaptive filtering techniques in passive radar
, Article Proceedings International Radar Symposium, Dresden ; Volume 2 , June , 2013 , Pages 1067-1078 ; 21555753 (ISSN) ; 9783954042234 (ISBN) ; Radmard, M ; Majd, M. N ; Nayebi, M. M ; Sharif University of Technology
2013
Abstract
One of the most important obstacles in passive radar applications is removing the direct signal from the target channel. Otherwise, week echoes from the targets in the target channel would be ignored due to the limited dynamic range of the system. One of the most effective techniques in this field is using adaptive filters. In this paper various adaptive filters are introduced and their performances are shown and compared
Ambiguity function based receiver placement in multi-site radar
, Article 2016 CIE International Conference on Radar, RADAR 2016, 10 October 2016 through 13 October 2016 ; 2017 ; 9781509048281 (ISBN) ; Chitgarha, M. M ; Nazari Majd, M ; Nayebi, M. M ; Sharif University of Technology
2017
Abstract
It has been shown that using multiple antennas in a radar system improves the performance considerably, since multiple target echoes are received from different aspect angles of the target. In this way, the target detection is improved. However, when using multiple antennas, some problems, such as designing the transmit signals, synchronization, etc. emerge that should be solved. One of such problems is the receiver placement. Receiver placement deals with choosing a proper position for the receive antenna in order to optimize the whole system's performance. In this paper, a receiver placement procedure based on improving the radar ambiguity function is proposed for the case of a multisite...
Improving MIMO radar's performance through receivers' positioning
, Article IET Signal Processing ; Volume 11, Issue 5 , 2017 , Pages 622-630 ; 17519675 (ISSN) ; Radmard, M ; Nazari Majd, M ; Nayebi, M. M ; Sharif University of Technology
Institution of Engineering and Technology
2017
Abstract
By employing the MIMO (multiple-input-multiple-output) technology in radar, some new problems emerged, that, in order to benefit the MIMO gains in radar, it was necessary to solve them suitably. One of such obstacles is determining the positions of receive antennas in a MIMO radar system with widely separated antennas (WS MIMO radar), since it is shown that the antennas' positions affect the whole system's performance considerably. In this study, a proper receivers' positioning procedure is proposed. To do this end, four criteria are developed based on the proposed MIMO detector and the MIMO ambiguity function. The simulations verify that the proposed positioning procedure improves the...
Silylation of hydroxy groups with HMDS under microwave irradiation and solvent-free conditions
, Article Phosphorus, Sulfur and Silicon and Related Elements ; Volume 177, Issue 2 , 2002 , Pages 289-292 ; 10426507 (ISSN) ; Saidi, M. R ; Bolourtchian, M ; Heravi, M. M ; Sharif University of Technology
2002
Abstract
Phenols and alcohols are silylated with hexamethyldisilazane (HMDS) under microwave irradiation in solvent-free condition in good to excellent yields