Sharif Digital Repository

Decellularized extracellular matrix (dECM) bioinks hold significant potential in the 3D bioprinting of tissue-engineered constructs (TECs). While 3D bioprinting allows for the creation of custom-designed TECs, the development of bioinks based solely on dAM, without the inclusion of supporting agents or chemical modifications, remains underexplored. In this study, we present the concentration-dependent printability and rheological properties of dAM bioinks, along with an analysis of their in vitro cellular responses. Our findings demonstrate that increasing dAM concentrations, within the range of 1 to 3% w/v, enhances the mechanical moduli of the bioinks, enabling the 3D printing of flat... 

Recently, decellularized amniotic membrane-derived hydrogels (DAMHs) have received significant attention for wound care, ocular surface reconstruction, and chondral healing. Despite the advantages of DAMHs for tissue engineering (TE), the loss of structural components during the decellularization process mitigates their mechanical strength and thus limits their practical application. Herein, we present a method for the surface modification of two-dimensional nanosilicates (laponite) as a rheological modifier to tailor the properties of DAMHs. Results show that after introducing nanosilicates, severe aggregation of the nanoparticles occurs, owing to the shielding effect of ions on the surface... 

Recently, decellularized amniotic membranes (dAM) have attracted significant interest as a valuable source for the development of shear-thinning hydrogels and bioinks. However, the inferior rheological behavior and weak mechanical durability restrict the printability of the hydrogels and their stability after three-dimensional (3D) bioprinting. Therefore, a chemical or physical modification with biocompatible components is necessary to improve dAM-derived hydrogels’ properties. The present study proposes a strategy to fabricate printable dAM-derived hydrogels (DAMHs) supplemented with sodium alginate and Laponite nanoplatelets. Rheological experiments determined the key role of Laponite... 

Although hydrogels developed based on the decellularized amniotic membrane (dAM) hold great promise for tissue engineering and regenerative medicine, the development of printable bioinks faces serious limitations considering appropriate rheological behavior and shape fidelity after 3D printing. To improve the printability of dAM, we propose that hydroxyethyl cellulose (HEC) and silicate nanoplatelets (Laponite) can be used as a thickening agent and rheology modifier, respectively. It is shown that the Laponite operates as a physical crosslinking agent through reversible non-covalent interactions between nanoplatelets and the biopolymer matrix, thus improving the storage modulus of the bioink... 

Decellularized amnion (dAM)-derived hydrogels have been extensively exploited for versatile medical and therapeutical applications, particularly for soft tissue engineering of skin, vascular graft, and endometrium. In contrast to polyacrylamide-based hydrogels, which have been extensively employed as a 3D cell culture platform, the cell response of dAM hydrogel is yet to be understood. In this study, we have prepared hydrogels containing different concentrations of dAM and systematically investigated their microstructural features, gelation kinetics, and rheological properties. The results show that dAM hydrogels possess a network of fibers with an average diameter of 56 ± 5 nm at 1% dAM,... 

In recent years, the amnion (AM) has emerged as a versatile tool for stimulating tissue regeneration and has been of immense interest for clinical applications. AM is an abundant and cost-effective tissue source that does not face strict ethical issues for biomedical applications. The outstanding biological attributes of AM, including side-dependent angiogenesis, low immunogenicity, anti-inflammatory, anti-fibrotic, and antibacterial properties facilitate its usage for tissue engineering and regenerative medicine. However, the clinical usage of thin AM sheets is accompanied by some limitations, such as handling without folding or tearing and the necessity for sutures to keep the material... 

Inclusion of nano-clays into hydrogels is an efficient approach to produce nanocomposite hydrogels. The introduction of nano-clay into hydrogels causes an increase in water absorbency. In the present work, Nanocomposite hydro-gels based on kappa-carrageenan were synthesized using sodium montmorillonite as nano-clay. Acrylamide and meth-ylenebisacrylamide were used as monomer and crosslinker, respectively. The structure of nanocomposite hydrogels was investigated by XRD and SEM techniques. Swelling behavior of nanocomposite hydrogels was studied by varying clay and carrageenan contents as well as methylenebisacrylamide concentration. An optimum swelling capacity was achieved at 12% of sodium... 

This study presents an electrochemical procedure for synthesizing graphene oxide (GO) nanosheets in a diluted acidic medium (0.05 M), featuring 100% synthesis yield. Characterization results revealed that the synthesized GO in this approach exhibits a low XRD peak position (around 10°) and a C/O ratio of 2.9, offering higher surface functionality than conventional electrochemical methods reported in the literature. We also demonstrated the tunability of the GO's surface functionality by manipulating the synthesis parameters, such as electrolyte concentration and synthesis time, offering flexibility that surpasses the constraints often seen in chemical methods. Additionally, it was observed... 

In the present study, the out-of-phase thermomechanical fatigue (OP-TMF) behavior of a cast aluminum-silicon-magnesium alloy, the A356.0 alloy which has been widely used in diesel engine cylinder heads, is compared to room-temperature and high-temperature low cycle fatigue (RT-, HT-LCF) behaviors. For this purpose, strain/temperature-controlled isothermal and non-isothermal fatigue tests were performed based on realistic loading conditions in cylinder heads. Fatigue tests results showed that the plastic strain increased during cycles under constant mechanical strain amplitude, while the specimen failed. Under LCF loadings, the cyclic hardening occurred at low temperatures for the A356.0... 

Machine learning (ML) is generating new opportunities for innovative research in energy economics and finance. We critically review the burgeoning literature dedicated to Energy Economics/Finance applications of ML. Our review identifies applications in areas such as predicting energy prices (e.g. crude oil, natural gas, and power), demand forecasting, risk management, trading strategies, data processing, and analyzing macro/energy trends. We critically review the content (methods and findings) of more than 130 articles published between 2005 and 2018. Our analysis suggests that Support Vector Machine (SVM), Artificial Neural Network (ANN), and Genetic Algorithms (GAs) are among the most... 

The general approach to fault tolerance in uniprocessor systems is to maintain enough time redundancy in the schedule so that any task instance can be re-executed in presence of faults during the execution. In this paper a scheme is presented to add enough and efficient time redundancy to the Earliest-Deadline-First (EDF) scheduling policy for periodic real-time tasks. This scheme can be used to tolerate transient faults during the execution of tasks. We describe a recovery scheme which can be used to re-execute tasks in the event of transient faults and discuss conditions that must be met by any such recovery scheme. For performance evaluation of this idea a tool is developed. © 2007 IEEE  

The reliable transfer in Network on Chips (NoCs) can be threatened by crosstalk fault occurring in wires. Crossstalk fault is due to inter-wire coupling capacitance that based on the patterns of transitions appearing on the wires, significantly limits the reliability of NoCs. Among these transitions, 101 and 010 bit patterns impose the worst crosstalk effects to wires. This work intends to increase the reliability of NoCs against crosstalk faults by applying an improved Fibonacci-based numeral system, called Doubled-Penultimate Fibonacci (DP-Fibo). In the DP-Fibo coding algorithm, code words without ‘101’ and ‘010’ bit patterns are produced to reduce crosstalk faults. Experimental results... 

In the present work, specimens were cut out from St-37 plates with 19 mm thickness. The thickness of plates was reduced to 12.5 mm by milling and grinding operations. Then a standard V-shaped fillet was made on one edge of the plates. Two plates were butt-welded by standard metal arc gas (MAG) welding process. Residual stresses induced by welding were measured on 20 specimens by centre hole drilling. Load controlled axial fatigue tests were carried out to determine the fatigue life of specimens. Crack growth rates were obtained from experiment. Fractography of specimens was performed. Genetic Algorithm (GA) was employed for prediction of residual stress value in weldments using the crack... 

In this work, we implement some analytical techniques such as the Exp-function, Tanh, and extended Tanh methods for solving nonlinear partial differential equation, which contains sine terms, its name Double Sine-Gordon equation. These methods obtain exact solutions of different types of differential equations in engineering mathematics  

The qualitative effects of residual stress parameters on fatigue crack growth are investigated using Monte Carlo probabilistic analysis technique. These parameters include the maximum residual stress,σ0, half-width of the tensile residual stress region, b, and the redistribution of residual stress parameter, β. A normal distribution is assumed for all parameters considered in the investigation and fatigue life is determined using Forman equation. The results indicate that: (i) fatigue life decreases nonlinearly if the mean of random maximum residual stress and the half-width of tensile residual stress region increases; (ii) fatigue life increases nonlinearly if the rate of residual stress... 

In this paper residual stresses induced by butt metal arc gas welding (MAGW), in accordance with ASTM E837, are determined by hole drilling. The results are analyzed by probabilistic methods. Also, the effect of fatigue life on relaxation of welding residual stress is investigated. The specimens are tested to measure fatigue life and crack growth rates in accordance with ASTM E466 for force controlled amplitude axial fatigue testing. © 2008 Verlag Stahleisen GmbH, Düsseldorf  

The effect of contact geometry on fretting fatigue life was investigated by experiments and numerical simulation. The experiments were conducted for flat and cylindrical pads under the same contact normal force. The post-test examinations including crack growth measurements and fractography were carried out using optical and scanning electron microscopy (SEM). Numerical simulations of pad-specimen assembly with and without crack were performed using a finite element (FE) analysis. The experimental study revealed that the rate of crack growth was higher at the early stages of fretting fatigue for cylindrical pads. This stage corresponds to a higher KII for cylindrical contact model. After... 

A variational theory (VT), in which the potential energy of a real system is evaluated relative to the hard-sphere system, was used to investigate the medium's effects on the pair potential parameters. By adding the medium's effects to the isolated pair potential, the concept of an 'effective pair potential' (EPP) was introduced. The EPP parameters were compared with those of the average effective pair potential (AEPP) for Ar, which showed the importance of the medium effects and the long range interactions of the AEPP in dense fluids. The study showed that the depth parameter of the AEPP is much larger than that of the EPP