Sharif Digital Repository

Efficient utilization of runways, as major bottlenecks at airports, not only minimizes flight delays but also plays a vital role in reducing fuel emissions and mitigating environmental impacts. Aircraft scheduling problem studied in this paper seeks to improve this efficiency through optimally scheduling departure/arrival aircraft on multiple runways. The primary innovation of this study lies in accounting for aircraft taxi times between runways and gates, as well as the landing delay patterns, which have not been simultaneously addressed in the literature. To solve the problem, an enhanced branch-and-price method has been developed, improving upon existing approaches in the literature. It... 

This research addresses the challenge of controllability in computational antibody design using generative diffusion models, particularly RFantibody. Although these models have demonstrated success in generating diverse antibody structures, they still face limitations in steering the generative process toward specific design goals and directly optimizing binding affinity. The main innovation of this study lies in introducing two external guiding potentials during inference, which enhance the generation process in a modular manner without retraining the model. The first potential, focusing on interface hotspots, directs the antibody toward the desired epitope. The second potential, inspired...