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The present work was aimed to account a green and eco-friendly synthesis of palladium nanoparticles using Rosmarinus officinalis leaves extracts for the first time, therefore, that can be an acceptable replacement for chemical media to improve potential biological properties. The synthesized palladium nanoparticles were fully characterized using FT-IR, XRD, FESEM, TEM and UV/Vis spectroscopy techniques. Catalytic activity was investigated by Mizoroki-Heck reaction, and optimized based on solvent, temperature and time of the reaction, and the best results were found in water as a green media without any additional reagents. Biological activity of the synthesized nanoparticles were evaluated... 

Due to rapid development of manufacturing process, composite materials with porosity have attracted commercially notices in advanced engineering applications. For this regard, buckling and vibrational characteristics of a porous composite cylindrical nanoshell reinforced with GPLs is investigated in this paper. The material properties of piece-wise graphene-reinforced composites (GPLRC) are assumed to be graded in the thickness direction of a cylindrical nanoshell and are estimated using a nanomechanical model. The novelty of our work is including the effects of porosity and GPLRC on natural frequency, critical axial load and critical temperature of the GPLRC cylindrical nanoshell. The... 

In this article, wave propagation characteristics of a size-dependent laminated composite nanostructure coupled with a piezoelectric actuator (PA) is investigated. In order to consider the effects of small scale, the governing equations of the laminated composite nanostructure coupled with PA are derived using Hamilton’s principle based on the nonlocal strain gradient theory (NSGT). The differential equations of motion are solved with the assistance of the analytical method. Afterward, a parametric study is carried out to investigate the effects of the PA thickness, wave number, angular velocity and the ply angle on the value of phase velocity. The results show that the ply angle plays an... 

Introduction: In recent years, the use of cost-effective, multifunctional, environmentally friendly and simple prepared nanomaterials/nanoparticles have been emerged considerably. In this manner, different synthesizing methods were reported and optimized, but there is still lack of a comprehensive method with multifunctional properties. Materials and Methods: In this study, we aim to synthesis the copper oxide nanoparticles using Achillea millefolium leaf extracts for the first time. Catalytic activity was investigated by in situ azide alkyne cycloaddition click and also A3 coupling reaction, and optimized in terms of temperature, solvent, and time of the reaction. Furthermore, the... 

Doxorubicin (DOX) is a potent anti-cancer agent and there have been attempts in developing nanostructures for its delivery to tumor cells. The nanoparticles promote cytotoxicity of DOX against tumor cells and in turn, they reduce adverse impacts on normal cells. The safety profile of nanostructures is an important topic and recently, the green synthesis of nanoparticles has obtained much attention for the preparation of biocompatible carriers. In the present study, we prepared layered double hydroxide (LDH) nanostructures for doxorubicin (DOX) delivery. The Cu–Al LDH nanoparticles were synthesized by combining Cu(NO3)2·3H2O and Al(NO3)3·9H2O, and then, autoclave at 110. The green... 

Nanoparticles and nanomaterials in cancer therapy as well as in all biomedical applications have been heavily investigated over the last decade. In this manner, green synthesized nanomaterials have been vastly considered as promising, cost effective, and environmentally friendly components. Also, green synthesis methods could reduce cytotoxicity as well as increase the biocompatibility of the final products. In this chapter, the role of nanomaterials obtained from biowaste specifically for cancer therapy is discussed. © 2023 Elsevier Ltd. All rights reserved  

In recent years, many efforts have been made in the field of computational modeling of cancerous tumors, in order to obtain a better understanding and predictions of their growth patterns. Furthermore, constraint-based modeling of metabolic networks has become increasingly popular, which is appropriate for the systems-level reconstruction of cell physiology. The goal of the current study is to integrate a multiscale agent-based modeling framework with a constraint-based metabolic network model of cancer cells in order to simulate the three dimensional early growth of avascular tumors. In order to develop the integrated model, a previously published generic metabolic network model of cancer... 

In this study, the instability and bifurcation diagrams of a functionally graded (FG) porous sandwich beam on an elastic, viscous foundation which is influenced by an axial load, are investigated with an analytical attitude. To do so, the Timoshenko beam theory is utilized to take the shear deformations into account, and the nonlinear Von-Karman approach is adopted to acquire the equations of motion. Then, to turn the partial differential equations (PDEs) into ordinary differential equations (ODEs) in the case of equations of motion, the method of Galerkin is employed, followed by the multiple time scale method to solve the resulting equations. The impact of parameters affecting the response... 

Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNi2S4, and the porphyrins were incorporated into the layers as well to increase the sensitivity of the prepared nanostructure. The prepared nanocomposite can establish π–π interactions between the genetic material and on the surface of porphyrin rings. Also, hydrogen bonds between genetic domains and the porphyrin’ nitrogen and the surface hydroxyl groups are probable. Furthermore, the potential donor–acceptor relationship between the d7 transition metal, cobalt, and the genetic material provides a suitable... 

Correction to: Scientific Reports, published online 23 March 2021 The original version of this Article contained errors in the Results section resulting from an incomplete revision of the text to reflect changes in the figures during review. Figure legends and the Results section were corrected accordingly. As a result, in the Results section, under the subheading ‘In situ and real-time monitoring of hydrogen peroxide from the living cell’, the original legend of Figure 4 “Fluorescent image of the cells seeded on the nanocomposite after 16 h, for HEK-293 cell line (a,b) and PC12 cell line (c,d). (b,d) represents the fluorescence image after + 1 s after (a,c) captures. Fluorescence emission... 

Evaluation of the effect of different parameters for designing a non-viral vector in gene delivery systems has great importance. In this manner, 2D crystals, precisely layered double hydroxides, have attracted the attention of scientists due to their significant adjustability and low-toxicity and low-cost preparation procedure. In this work, the relationship between different physicochemical properties of LDH, including pH, size, zeta potential, and synthesis procedure, was investigated and optimized for CRISPR/Cas9 delivery and reverse fluorescence response to the EGFP. In this manner, ZnAl LDH and ZnAl HMTA LDH were synthesized and characterized and applied in the HEK-293 cell line to... 

The future of power systems known as smart grids is expected to involve an increasing level of intelligence and incorporation of new information and communication technologies in every aspect of the power grid. Demand response resources and gridable vehicle are two interesting programs which can be utilized in the smart grid environment. Demand response resources can be used as a demand side virtual power plant (resource) to enhance the security and reliability of utility and have the potential to offer substantial benefits in the form of improved economic efficiency in wholesale electricity markets. An economic model of incentive responsive loads is modelled based on price elasticity of... 

Pure and Pd-doped WO3 Nanocrystalline tungsten oxide films on alumina substrates were prepared via sol-gel method from peroxopolytungstic acid. AFM, XRD, SEM, XPS methods were used to determine the surface morphology, grain size and layer composition. XRD analysis showed WO3 nanocrystalline particles in monoclinic phase and with average size of about 333nm, which was consistent with SEM analysis results. Sensing properties of samples toward H2 gas was studied. The sensitivity of WO3 nanocrystalline films was about 4 at 2300ppm (0.2%) H2 gas. Introducing Pd to the system led to an increase in the sensitivity about 2 orders of magnitude. The sensitivity of Pd: WO3 was about 400 at 2300ppmH2  

A new Quantitative Structure-Retention Relationship (QSRR) approach was carried out for prediction of gas-liquid retention times of 124 psychiatric drugs in whole blood on fused-silica capillary column coated with crosslinked methylsilicone with nitrogen-phosphorus detection. After screening the descriptors, a total of 699 topological, geometric, and electronic descriptors (zero-to three-dimensional) representing various structural characteristics were calculated for each molecule in the dataset. Combined method of Classification and Regression Tree (CART) as a feature selection method for the extraction of four relevant descriptors and Adaptive Neuro-Fuzzy Inference System (ANFIS) as a... 

This study, for the first time, reports the synthesis of CuO- and Cu2O nanoparticles (NPs) using the Salvia hispanica extract by a high-gravity technique. The original green synthesis procedure led to the formation of nanoparticles with promising catalytic and biological properties. The synthesized nanoparticles were fully characterized and their catalytic activity was evaluated through a typical Azide-Alkyne Cycloaddition (AAC) reaction. The potential antibacterial activity against gram positive (S. aureus) and gram negative (E. coli) bacteria were investigated. It was shown that the antibacterial properties were independent of the NP morphology as well as of the texture of the synthesis... 

This study investigated the synthesis of Pd nanoparticles (NPs) using a high-gravity technique mediated by Salvia hispanica leaf extracts. Biological assays confirmed their antibacterial activity against gram positive (S. aureus) and gram negative (E. coli) bacteria with significant antioxidant activity in comparison with the standards as well as low cellular toxicity on PC12 and HEK293 cell lines. To the best of our knowledge, this study can be considered as the first investigation of Pd-NPs synthesized by Salvia hispanica leaf extracts assisted by a high-gravity technique. In addition, the mentioned green synthesis procedure led to the formation of nanoparticles with considerable... 

Herein, the NH2-UiO-66 metal organic framework (MOF) has been green synthesized with the assistance of high gravity to provide a suitable and safe platform for drug loading. The NH2-UiO-66 MOF was characterized using a field-emission scanning electron microscope, transmission electron microscope (TEM), X-ray diffraction, and zeta potential analysis. Doxorubicin was then encapsulated physically on the porosity of the green MOF. Two different stimulus polymers, p(HEMA) and p(NIPAM), were used as the coating agents of the MOFs. Doxorubicin was loaded onto the polymer-coated MOFs as well, and a drug payload of more than 51% was obtained, which is a record by itself. In the next step, pCRISPR was... 

A Quantitative Structure-Retention Relationship (QSRR) study of 32 benzodiazepines is performed in this work. Two feature selection methods of Adaptive Neuro Fuzzy Inference System (ANFIS) and a stepwise regression approach adopted for the Multiple Linear Regressions (MLR) were used to predict the Liquid Chromatography-Mass Spectrometry (LC-MS) Retention Time (RT) of these compounds on a Xterra MS C-18 stationary phase. ANFIS and MLR methods were used as variable selection tools and a neural network was employed for predicting the RTs. Tbree descriptors of 3D-MoRSE-signal 06/weighted by atomic polarizabilities (Mor06p), Radial Distribution Function-1.0/weighted by atomic van der Waals... 

Carbon-based nanocarriers such as multiwall carbon nanotubes (MWCNTs) and reduced graphene oxide (rGO) have shown promising delivery capabilities due to their low immunogenicity, superior internalization, and suitable cell penetration efficiency. Herein, a molecular engineering strategy is advanced for the one-pot synthesized rGO/MWCNT/Fe3O4/ZnO to enhance the stability of the nanocarrier in the biological matrix; green synthesized ZnO was responsible for water uptake and reduced cytotoxicity, while Fe3O4controlled the cellular internalization for gene delivery. Surface morphology of the ensuing nanocomposite was correlated with photocatalytic and gene delivery (CRISPR/Cas9) features. For... 

Nanostructured TiO2 hollow fibers have been prepared using natural cellulose fibers as a template. This cheap and easily processed material was used to produce highly porous photoanodes incorporated in dye-sensitized solar cells and exhibited remarkably enhanced electron transport properties compared to mesoscopic films made of spherical nanoparticles. Photoinjected electron lifetime, in particular, was multiplied by 3-4 in the fiber morphology, while the electron transport rate within the fibrous photoanaode was doubled. A nearly quantitative absorbed photon-to-electrical current conversion yield exceeding 95% was achieved upon excitation at 550 nm and a photovoltaic power conversion...