Sharif Digital Repository

Injectable hydrogels are a promising treatment option for nervous system injuries due to the difficulty to replace lost cells and nervous factors but research on injectable conductive hydrogels is limited and these scaffolds have poor electromechanical properties. This study developed a chitosan/beta-glycerophosphate/salt hydrogel and added conductive aligned nanofibers (polycaprolactone/gelatin/single-wall carbon nanotube (SWCNT)) for the first time and inspired by natural nerve tissue to improve their biochemical and biophysical properties. The results showed that the degradation rate of hydrogels is proportional to the regrowth of axons and these hydrogels’ mechanical (hydrogels without... 

We study the kidney market in Iran. The most effective treatment for end-stage renal disease is a kidney transplant. While the supply of cadaveric kidneys is limited, the debate has been focused on the effects of the existence of a free market for human organs. Economists as well as medical and legal researchers are divided over the issue. Iran has a unique kidney market which has been in place for over 20 years, frequently reporting surprising success in reducing the waiting list for kidneys. This paper demonstrates how the Iranian system works  

This study proposes a mathematical model to evaluate the impact of oxygen carriers and scaffold geometry on oxygen distribution and cell growth in a 3D cardiac construct using computational fluid dynamics (CFD). Flow equations, oxygen balance equation and cell balance equation were solved using special initial and boundary conditions. The modeling results revealed that 55% increase in cardiac cell density occurred by using 6.4% perfluorocarbon oxygen carrier (PFC) compared to pure culture medium without PFC supplementation. Moreover, the effects of the scaffold geometry on cell density were examined by changing the channel numbers and the construct length. A 30% increase in the average cells... 

Many bitumen reservoirs contain shale layers of varying thickness, lateral extent, and frequency. These shale layers, depending on their size, vertical and horizontal locations, and continuity throughout the reservoir, may act as a flow barrier and severely reduce vertical permeability of the pay zone and slow down the steam-assisted gravity drainage steam chamber development. Therefore, to improve productivity in these reservoirs, understanding of the effects of reservoir heterogeneities has become necessary. This work presents numerical investigation of the effects of shale barriers on steam-assisted gravity drainage performance when applied to produce mobile heavy oil. The most concern of... 

The aim of this contribution is to evaluate the performance of an expanding solvent steam assisted gravity drainage (ES-SAGD) process in naturally fractured systems. Steam-assisted gravity drainage (SAGD) and ES-SAGD processes have been investigated in both conventional and fractured reservoir models and the effect of networked fractures on the recovery mechanism and performance of ES-SAGD has been investigated. Operational parameters such as steam quality, vertical distances between wells, and steam injection temperature have been also evaluated. Finally, to study the effect of a well's horizontal offset, a staggered ES-SAGD well configuration has been compared to a stacked ES-SAGD  

The Steam Assisted Gravity Drainage (SAGD) process, a developed Enhanced Oil Recovery (EOR) process to recover oil and bitumen, has been studied theoretically and experimentally in conventional reservoirs and models and is found a promising EOR method for certain heavy oil reservoirs. In this work simulation studies of the SAGD process were made on different fractured models consisting of fractures in both Near Well Region (NWR) and Above Well Region (AWR) and even in the presence of networked fractures. At early stage of the SAGD process in fractured system, steam moves through the fractures first and then the matrix blocks are heated primarily by conduction and possibly some steam... 

Harnessing neural stem cells to repair neuronal damage is a promising potential treatment for neuronal diseases. To enable future therapeutic efficacy, the survival, proliferation, migration and differentiation of neural stem/progenitor cells (NPCs) should be accurately studied and optimized in in vitro platforms before transplanting these cells into the body for treatment purposes. Such studies can determine the appropriate quantities of the biochemical and biomechanical factors needed to control and optimize NPC behavior in vivo. In this study, NPCs were cultured within a microfluidic device while being encapsulated within the collagen matrix. The migration and differentiation of NPCs were... 

The main goal of this study is to consider the simultaneous effect of the surface gradient and the temperature changes on nano-machine migration on gold substrates. By so doing, we hypothesize that nano-machines will experience minimal deviation, which leads them to have a long-range movement even at low temperatures (75 K and 150 K). To this end, the diffusive motion of C60, nanocar, and nanotruck on the conical and concave gold substrates with different radius gradients has been investigated. In order to better understand the effects of chassis and surface interactions on nano-machine movement, an all-atom model and classic atomistic dynamics have been utilized. According to the results,...