Sharif Digital Repository

Infection is a disease that is mainly caused by different Gram-negative and Gram-positive bacteria. Treatment of infections requires a considerable amount of antibiotics, which can cause serious damage to the patient's body. Delivering the antibiotic only to the site of infection can prevent these destructive effects, such as the destruction of the normal intestinal flora. The drug delivery system through carriers will take antibiotics into a part of the body involved in the disease. Niosome nanoparticles, which have been made from non-ionic surfactants, have been emerging as ideal drug/antibiotics delivery vehicles. Recently, niosome formulations have been targeted to reduce toxicity and... 

Recent advances in osteoimmunology have led the focus on the immunomodulatory design of metal–organic framework (MOF)-based porous materials for encouraging bone repair by influencing the immune microenvironment using implanting biomaterials. Despite the growing interest in porous materials, few research studies have been done on how extracellular Sr2+ and Ca2+ loaded in MOFs leads the organism toward optimal osteogenesis. In this study, in vitro evaluations showed that both Sr2+ and Ca2+ nanoparticles have a dual effect, stimulating matrix secretion by osteoblasts while suppressing matrix resorption by osteoclasts. Sr2+ significantly increased RUNX2 transcriptional activity and... 

Natural biomaterials were used to decorate UiO-66-NH2 to develop a platform for co-drug delivery of doxorubicin and sorafenib as a cost-effective and easy way to use a drug delivery system (DDS). To properly characterize the modified MOFs, standard analytical methods were used. Then doxorubicin and sorafenib were loaded into and onto the porosity of the MOF, UiO-66-NH2. The surface morphological analysis, FESEM, and TEM images revealed the hexagonal structure of the UiO-66-NH2, demonstrating the successful synthesis of these green MOFs. Internalization and loading of doxorubicin on the MCF-7 cell line was investigated with two-dimensional fluorescence microscopy, which shows that drug... 

A one-pot synthesis method was conceptualized and implemented to develop green carbon-based nanocomposites working as biosensors. Porphyrin was synthesized to adorn the surface of nanocomposites making them highly sensitive for giving rise to π-π interactions between the genetic materials, proteins and porphyrin rings. The hydrogen bond formed between the proteins (analytes) and the nitrogen in the porphyrin structure as well as the surface hydroxyl groups was equally probable. In this context, different forms of porphyrins were incorporated to explore the interrelationship between the surface morphology and the ability of detection of genetic material and/or proteins by the aid of the... 

Background: This research follows some investigations through neural tissue engineering, including fabrication, surface treatment, and evaluation of novel self-stimuli conductive biocompatible and degradable nanocomposite scaffolds. Methods: Gelatin as a biobased material and polyvinylidene fluoride (PVDF) as a mechanical, electrical, and piezoelectric improvement agent were co-electrospun. In addition, polyaniline/graphene (PAG) nanoparticles were synthesized and added to gelatin solutions in different percentages to induce electrical conductivity. After obtaining optimum PAG percentage, cold atmospheric plasma (CAP) treatment was applied over the best samples by different plasma variable... 

Curcumin, an important natural component of turmeric, has been known for a long time for its antimicrobial properties. This study aimed to investigate the anti-biofilm action of the niosome-encapsulated curcumin and explore the involved anti-biofilm mechanism. In silico investigations of ADME-Tox (absorption, distribution, metabolism, excretion, and toxicity) were first performed to predict the suitability of curcumin for pharmaceutical application. Curcumin showed low toxicity but at the same time, low solubility and low stability, which, in turn, might reduce its antimicrobial activity. To overcome these intrinsic limitations, curcumin was encapsulated using a biocompatible niosome system,... 

In this study, bentonite nanoclay (BNC) impregnated chitosan-g-gelatin (CS-g-GEL/BNC) nanocomposite hydrogels were prepared with multi-features including being cost-effective, high-performance, biodegradable, and easy to separate for Congo red (CR) dye adsorption. Various characterization techniques, including FTIR, XRD, SEM, TGA, and EDX, were used to verify the successful formulation of the prepared hydrogels. The results revealed that the thermal stability of CS-g-GEL/BNC nanocomposite hydrogel was improved compared to CS-g-GEL hydrogel. CR dye also reached its equilibrium adsorption quickly and effectively at 60 min. When bentonite clay nanoparticles content was increased to 10 %, the... 

In the current study, the physicochemical and biological properties of tetracycline-loaded core-shell nanoparticles (Tet/Ni0.5Co0.5Fe2O4/SiO2 and Tet/CoFe2O4/SiO2) were investigated. The antibacterial activity of nanoparticles alone and in combination with tetracycline was investigated against a number of Gram-positive and Gram-negative bacteria for determining minimum inhibitory concentration (MIC) values. The MIC of Tet/Ni0.5Co0.5Fe2O4/SiO2 nanoparticles turned out to be significantly higher than that of Tet/CoFe2O4/SiO2 nanoparticles. Furthermore, Tet/Ni0.5Co0.5Fe2O4/SiO2 nanoparticles exhibited potent antibiofilm activity against pathogenic bacteria compared to Tet/CoFe2O4/SiO2... 

In this study, in-silico properties of Gingerol (Gin) and Letrozole (Let), as two potential anti-cancer drugs, were investigated and some significant ADME drawbacks were predicted. Accordingly, to address the drawbacks, mesoporous silica nanoparticles (MSNs) were prepared, functionalized with zinc, amine, and graphene oxide (GO) (MZNG), and employed for loading and delivery of the both to breast cancer cells in-vitro. Biophysical analysis showed that Let and Gin-loaded MZNGs have spherical structure with a mean diameter of ∼210 nm. The MZNGs provided high entrapment efficiency of Let and Gin with a pH-sensitive sustained release profile. The cytotoxicity assay demonstrated that loading of... 

Breast cancer is the most common invasive cancer in women and the second leading cause of cancer death in women after lung cancer. The purpose of this study is a targeted delivery toward in vitro (on MCF7 and 4T1 breast cancer cell lines) through niosomes-based nanocarriers. To this end, different bioactive molecules, including hyaluronic acid (HA), folic acid (FA), and polyethylene glycol (PEG), were used and compared for surface modification of niosomes to enhance endocytosis. FA-functionalized niosomes (Nio/5-FU/FA) were able to increase cell cytotoxicity and reduce cell migration and invasion compared to PEG-functionalized niosomes (Nio/5-FU/PEG), and HA-functionalized niosomes... 

Call admission control schemes are crucially Important concepts ID researches on cellular mobile networks. One of them is the new thinning scheme. In this study we define a confidence interval for threshold and the numerical results show the performance of the scheme in defined interval. Also we discuss the sensitivity of the scheme (in sample-based sensitivity method) at different thresholds. The results show the better performance in confidence thresholds and sensitivity of scheme into variations of thresholds  

This paper presents a new model of call admission control which consists of a few key elements for protecting the network in different conditions of workload in a manner that, calls blocking /dropping are kept under desired level. This model consists of two traffic classes of voice and data. In order to give a priority to handoff call over new call, some parameters in this model are adjusted in a manner that handoff dropping is reduced to the least probability in the target cell and the adjacent cells. Some channels are reserved for voice and data calls in each cell to guarantee the quality of service requirements in the network. Limited fractional guard channel is used to have an optimized... 

Herein, a magnetic zirconium-based metal-organic framework nanocomposite was synthesized by a simple solvothermal method and used as an adsorbent for the removal of direct and acid dyes from aqueous solution. To enhance its adsorption performance, poly(propyleneimine) dendrimer was used to functionalize the as-synthesized magnetic porous nanocomposite. The dendrimer-functionalized magnetic nanocomposite was characterized by field-emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, nitrogen adsorption/desorption isotherms, and vibration sample magnetometer. The obtained results revealed the successful synthesis and functionalization of the... 

Integral abutment bridges have many advantages over bridges with expansion joints in terms of economy and maintenance costs. However, in the design of abutments of integral bridges temperature loads play a crucial role. In addition, seismic loads are readily transferred to the substructure and affect the design of these components significantly. Currently, the European and American bridge design codes consider these two load cases separately in their recommended design load combinations. In this paper, the importance and necessity of combining the thermal and seismic loads is investigated for integral bridges. A 2D finite element combined pile-soil-structure interactive model is used in this...