Sharif Digital Repository

Background and objective:Doxorubicin (DOX) is a known anticancer drug which is widely used in cancer therapy. Carbon nanotubes (CNTs) are among the most promising platforms for smart drug delivery applications. However, due to the toxicity and their low sulubility their application is limited and their functionalization with wide range of biomolecules are suggested. Therefore, the functionalized carbon nanotubes (f-CNT) with carboxyl (CNT-COO) and folic acid (CNT-COO-FA) were investigated as drug-carrier. Methods: Molecular dynamics (MD) simulation along with the Density Functional Theory (DFT) methods are being used to study the drug loading process on functionalized carbon nanotubes.... 

This study focuses on a forward looking approach in which deep eutectic solvents (DESs), a new class of designer solvents, were impregnated into micro porous polyvinylidene fluoride (PVDF) membrane for the separation of CO2 from CH4. Three types of DESs were prepared by mixing and heating of hydrogen bond acceptor (choline chloride) with either malic acid, tartaric acid or oxalic acid as hydrogen bond donor. The Fourier transform infrared spectroscopy confirmed the hydrogen bond interactions in the resulting DES. Thermal gravimetric analysis (TGA) was used to evaluate the thermal stability of the prepared membranes. The DES based supported liquid membranes were investigated systematically to... 

The safety of foods in terms of their sensory, chemical, physical, and human health, as well as their nutritional worth, have been recognized as having increased importance recently. The present study was carried out to examine the effects of dietary supplementation of sumac fruit powder on the meat quality of broiler chicks. A total of 135 broiler chicks (Ross 308) were randomly assigned to three dietary treatment groups, each group divided to three sub-groups of 15 birds each. The birds of T1 were fed standard diet as control group without supplementation, while the birds of T2 and T3 were fed standard diet with supplementation of 1g and 2g of sumac fruit powder/ kg feed, respectively. The... 

The study aimed to investigate the most effective leadership style that enhances the employees’ performance at the workplace and also evaluate the impact of leadership styles (Laissez-faire leadership, Transformational leadership, Transactional leadership,) on employees’ performance in the textile sector of Pakistan. The study explored the moderating role of Positive psychological capital to examine the relationship between leadership styles and employee performance. A quantitative research technique was used, and Data were collected from the lower to middle-level manager of the textile sector. The findings of this study showed that laissez-faire leadership has a significant but negative... 

The pertinence and importance of Darcy-Forchheimer flows can be found in large spectrum of engineering, biological and technological mechanisms like solar absorption and filtration, drainage problems, solar cells, ground stream hydrology, solar panels, irrigation and so forth. The major concern of this study is to interpret that how much a Darcy-Forchheimer flow of a micro-structured fluid (e.g., micropolar fluid) within a channel is influenced by the combined effects of static and oscillatory pressure gradients. Numerical treatment is carried out via three steps explicit Runge-Kutta method. Impacts of the preeminent parameters on the flow, mass and heat transport features of the problem are... 

Using the first-principles procedure of density-functional-theory within tight-binding approximation and nonequilibrium Green's function formalism, this paper reports on the impact of vacancy defects on the structural, electronic and transport properties of hydrogen-passivated graphene atomic sheet. After the introduction of vacancy defects in graphene atomic sheet passivated with hydrogen atoms, apart from increase in band gap, a suppression is noted in the intensity of transmission channels and density of states arising from the long array deformations of the graphene sheet and a corresponding shift of the Fermi level. This in turn decreases the conductance of the defected graphene atomic...