Loading...
Search for:
asadishad--bahareh
0.046 seconds
Investigation and Modeling of Polymer Electrolyte Membranes in PEM Fuel Cells
, M.Sc. Thesis Sharif University of Technology ; Roshandel, Ramin (Supervisor)
Abstract
Fuel cells convert the chemical energy of hydrogen and oxygen directly into the electricity. Their high efficiency and low emissions have made them a prime candidate for powering the next generation electric vehicles. Polymer electrolyte membrane is a key component of the PEM fuel cells. One of the critical problems to overcome in some PEM fuel cells is the water management because If there is not enough water, the membrane becomes dehydrated which leads to a rapid increase in ohmic resistance. On the other hand, if too much water is present, flooding may occur resulting in the pores of the gas diffusion filled by water and the available passage for reactant gases is decreased. In this work...
In vitro release behavior and cytotoxicity of doxorubicin-loaded gold nanoparticles in cancerous cells
, Article Biotechnology Letters ; Volume 32, Issue 5 , May , 2010 , Pages 649-654 ; 01415492 (ISSN) ; Vossoughi, M ; Alamzadeh, I ; Sharif University of Technology
2010
Abstract
Doxorubicin (DOX), a common cancer chemotherapeutics, was conjugated to folate-modified thiolated-polyethylene glycol-functionalized gold nanoparticles. The in vitro, controlled release behavior of DOX-loaded gold nanoparticles was observed using porous dialysis membranes (cut-off = 2 kDa). DOX-loaded gold nanoparticles had higher cytotoxicity for folate-receptor-positive cells (KB cells) compared to folate-receptor-negative cells (A549 cells) which were 48 and 62% viable for 10 μM doxorubicin, respectively. This indicates the potential of these nano-carriers for targeted-delivery. In addition, healthy cell viability was 69% for 10 μM free doxorubicin whereas for the same content of drug in...
Folate-receptor-targeted delivery of doxorubicin using polyethylene glycol-functionalized gold nanoparticles
, Article Industrial and Engineering Chemistry Research ; Volume 49, Issue 4 , 2010 , Pages 1958-1963 ; 08885885 (ISSN) ; Vossoughi, M ; Alemzadeh, I ; Sharif University of Technology
2010
Abstract
Doxorubicin-loaded nanocarriers were produced employing folate-modified polyethylene glycol (PEG)-functionalized gold nanoparticles for targeted delivery to positive folate-receptor cancer cells. Doxorubicin and folate were, respectively, conjugated to activated-folate and activated-PEG. The conjugates formed doxorubicin nanocarrier with an average size of 12 nm in diameter. The drug release response of functionalized gold nanoparticles was characterized by an initial rapid drug release followed by a controlled release. The doxorubicin nanocarriers showed higher cytotoxic effect on folate-receptor-positive cells (KB cells) than folatereceptor-negative cells (A549 cells). Cell viability in...
Synthesis of folate-modified, polyethylene glycol-functionalized gold nanoparticles for targeted drug delivery
, Article Journal of Dispersion Science and Technology ; Volume 31, Issue 4 , 2010 , Pages 492-500 ; 01932691 (ISSN) ; Vosoughi, M ; Alamzadeh, I ; Tavakoli, A ; Sharif University of Technology
2010
Abstract
The chemical synthesis and in vitro drug delivery response of folate-modified, polyethylene glycol-functionalized gold nanoparticles were studied. Lysine-capped gold nanoparticles were first prepared. Subsequently, the widely used anticancer agent doxorubicin (DOX) was successfully attached to the surface of folate-modified, polyethylene glycol-functionalized gold nanoparticles. Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to confirm the functionalization and conjugation steps in the chemical synthesis. The DOX-loading efficiency determined by UV-vis spectrometer was 80%. Drug release experiments displayed a controlled-release behavior...
Fabricate of Novel Drug Vector Based on Metallic Nanoparticles and Study of its Effects on Cell Line
, Ph.D. Dissertation Sharif University of Technology ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor)
Abstract
Application of nanoparticles in targeted delivery and controlled drug release is recently highly attracted especially in cancer therapy. In this study with the aim of developing a novel drug vector based on metallic nanoparticles, gold nanoparticles with their unique characteristics were used to design a vector for targeted anti-cancer drug delivery to tumor. First, gold nanoparticles were chemically synthesized therough sodium citrate and sodium brohydrate reductions with average diameters of 22 and 11 nm, respectively. Then, the activated poly ethylene glycol (PEG) and activated folic acid were conjugated to the lysine-capped gold nanoparticles. Subsequently, the widely used anticancer...