Sharif Digital Repository

Many experimental and theoretical studies have suggested that zinc binding to Aβ could promote amyloid-β aggregation and reactive oxygen species (ROS) production induced by AD disease. Therefore, the introduction of multifunctional drugs capable of chelating zinc metal ion and inhibiting Aβ aggregation is a promising strategy in the development of AD treatment. In present study molecular docking and molecular dynamics (MD) simulations were used to evaluate the efficacy of two new bifunctional peptide drug, composed of two different domains: C-terminal hydrophobic region of Aβ and Zn2+ chelator region. To evaluate the multifunctionality of the ligands, a comprehensive set of MD simulations up... 

In this study, simulation of two-phase water-oil compressible flow in naturally fractured reservoirs is studied. The studied reservoir has a 1D and horizontal ge-ometry that its properties such as porosity and permeability are homogeneous.Dual Porosity and Dual Porosity-Dual Permeability models are employed for simulation of reservoir. Reservoir descriptive equations are conservation of mass and momentum. Conservation of momentum equation is simplified by Darcy law and two-phase fluid flow is simulated with Black-oil model. Discretization of equations is done by finite volume method. In order to solve the equations of two-phase compressible fluid flow, the so-called IMPES (Implicit Pressure... 

Permeability is an essential parameter used for reservoir evaluation, simulation and management to optimize oil recovery. The conventional approach to estimate reservoir connectivity, conductivity, sweep efficiency and other critical information for decision-making is to build detailed geological models, which are then upscaled to a coarser grid where flow simulations are run. However, this takes many hours to be carried out even for a single realization practically. In practice, a very small number of realizations are considered and consequently the true uncertainty in the results is very poorly estimated. In this study, a statistical model of isotropic overlying sandbodies is used to... 

Metabonomics is a quantitative measurement of time dependent metabolic interactions for living systems in response to the pathological or genetic variations. NMR spectroscopy has emerged as a key tool for understanding metabolic processes in living systems. In this project, the study of metabolomics was performed as classification and regression on samples of parkinson’s disease, multiple sclerosis disease, celiac disease and crohn’s disease. In classification part, various methods were applied using optimal parameters.classification methods in Parkinson’s disease, multiple sclerosis disease, celiac disease and crohn’s disease were RF, CART, PLS-DA, RF and RF respectively. Based on the... 

Gravity dams are solid concrete structures that maintain their stability against design loads from the geometric shape and the mass and strength of the concrete. Because of their critical role in supplying portable and agricultural water and problems which would happen if they broke, it is required to consider their stability and keep them in safe conditions. They should be able to continue their function after a disaster such as earthquake. But most of them are aged dams with some have been built near faults. Indeed, there are some concerns regarding the performance of these dams under the effect of seismic loads. This research deals with performance evaluation of concerete gravity . The... 

Soil nailing is an in-situ technique of mechanically stabilizing soil masses which has been used in France, Germany, United states, and recently in Iran. A review of literature shows that Soil-Nailed walls have performed well during strong ground motions in comparison with the gravity retaining structures. After the 1989 Loma Prieta earthquake, minor signs of distress or corresponding deformation were found on the Soil-Nailed walls, indicating excellent performance of such structures during moderate and strong shakings. These observations indicate that Soil-Nailed walls have an inherent satisfactory seismic response. This has been attributed to the intrinsic flexibility of the Soil-Nailed... 

In nature, there are types of soils that when goinging under stress at constant moisture, or increase of moisture at constant stress, or change of both characters, they show a sudden and high level decrease in their volume. These type of soils are named as Collapsible soils. Iran is one of the countries that at some parts of its land collapsible soils are found. In this research by using of laboratory equipments, the volume change behavior of collapsible loess soils of Gorgan plain (North of Iran) is evaluated under increase of water content and inundation stress. In these experiments, the usual odeometer cell has been used for exploring the behaviour of collapsibility and volume change of... 

Collapsible soils such as loess, which are naturally found unsaturated, are kind of problematic soils that undergo sudden and noticeable decrease in volume under increasing stress at constant moisture, increasing moisture at constant stress, or increase in both of them. This kind of soil can be found in some parts of Iran such as plain of Gorgan. To fulfill the main purpose of this study, evaluating the effect of cementation on collapse behavior of loess of Gorgan, some oedometer tests under controlled matric suction were performed on reconstituted samples without and with lime. The lime was added for stabilizing of the collapsible materials and the amount was chosen to be %3 by weight of... 

Accurate prediction of relative permeability for various reservoir rocks at various saturation conditions has been of concern for a long time in petroleum industry. Relative permeability is known as one of the most significant parameters in simulation of actual multi-phase flow through porous media during life-time of a hydrocarbon reservoir. In addition, it plays important role in oil production and well completion. Direct experimental measurement in order to determine relative permeability of porous rock has long been recorded in petroleum related literature. However, empirical methods for determining relative permeability are becoming more widely used, particularly with the advent of... 

The concept of generalized strains is a well-established subject in the classical continuum mechanics. The characteristics and various applications of the generalized strains have been the point of interest of many researchers in the classical continuum mechanics. The aim of this thesis is the introduction of generalized strains in the micropolar theory, as a non-classical continuum theory. A set of generalized strains is suggested for the deformation of macro-elements. Moreover, a set of generalized strains is proposed for the micro-structures. Since the rate of strains possesses a significant importance in the constitutive equations of nonlinear analysis of solids, expressions for the rate... 

Collapsible soils are kinds of problematic soils which are susceptible to large and sudden reduction in volume upon wetting. A manifest kind of these soils is loess; catastrophic settlement of structures which are built upon it has been observed when the soil becomes wet. In this investigation the collapse potential of samples of loess taken from Gorgan, Golestan, Iran, has been studied by using unsaturated odometer tests under controlled matric suction. To this end, two modified odometer apparatus with the capability of controlling the matric suction, have been designed and developed. Undisturbed samples of soil have been tested under K0 condition, while the matric suction, volumetric... 

Concrete gravity dams are one of the most important infrastructures therefore their performance under seismic load is an important issue of concern for dam owners. It is necessary that these infrastructures to be able to continue their function after a disaster such as earthquake, as any damage can cause huge cost. For analysis of dams linear and nonlinear analyses are used. Because even operating loads will create cracks in the body of the dam, dam behavior can not always be considered linear. It is remarkable that these surface cracks can join together under seismic loads and this question the safety of dams. It is important to note that nonlinear analysis of concrete gravity dams is... 

Pile foundations suffered severe damages during the past earthquakes in all around the world. These damages were more severe in laterally spreading grounds and they mostly have been observed in gently sloping grounds and coastal areas. In these cases, Pile foundations not only are subjected to structures inertial loads and kinematic loads of liquefied soil but also lateral spreading intensifies damages. Thus, in the recent decade, several researches have been conducted to investigate the behavior of pile foundations in liquefiable and laterally spreading grounds, however, some uncertainties still remain in modeling of soil-pile interaction. In this study, the effects of liquefaction- induced... 

Generally concrete dams have not been sited at location where there were faults classified as active. However, there may be sites suitable for concrete dams where there is some possibility of fault displacement occurring underneath the dam. In addition, there may be situations where an existing dam was constructed over a fault thought to be inactive and later determined to be active, due to different approaches of classification of a fault whether it is active or not. Also some discontinuities may be observed during construction. For these cases nonlinear analysis and criteria will be required to assess the capability of concrete dams to safely withstand fault displacements. In this thesis,...