Sharif Digital Repository

Injectable hydrogels are a promising treatment option for nervous system injuries due to the difficulty to replace lost cells and nervous factors but research on injectable conductive hydrogels is limited and these scaffolds have poor electromechanical properties. This study developed a chitosan/beta-glycerophosphate/salt hydrogel and added conductive aligned nanofibers (polycaprolactone/gelatin/single-wall carbon nanotube (SWCNT)) for the first time and inspired by natural nerve tissue to improve their biochemical and biophysical properties. The results showed that the degradation rate of hydrogels is proportional to the regrowth of axons and these hydrogels’ mechanical (hydrogels without... 

In this study, the effect of distance-dependent dispersion coefficients on density-driven flow is investigated. The linear asymptotic model, which assumes that dispersivities increase linearly with distance from the source of contamination and reach asymptotic values at a large asymptotic distance, is employed. An in-house numerical model is adapted to handle distance-dependent dispersion. The effect of asymptotic-dispersion on aquifer contamination is analyzed for two tests: (i) a seawater intrusion problem in a coastal aquifer and (ii) a leachate transport problem from a surface deposit site. Global Sensitivity Analysis (GSA) combined with the Polynomial Chaos Expansion (PCE) surrogate... 

This study proposes a mathematical model to evaluate the impact of oxygen carriers and scaffold geometry on oxygen distribution and cell growth in a 3D cardiac construct using computational fluid dynamics (CFD). Flow equations, oxygen balance equation and cell balance equation were solved using special initial and boundary conditions. The modeling results revealed that 55% increase in cardiac cell density occurred by using 6.4% perfluorocarbon oxygen carrier (PFC) compared to pure culture medium without PFC supplementation. Moreover, the effects of the scaffold geometry on cell density were examined by changing the channel numbers and the construct length. A 30% increase in the average cells... 

In the bone tissue engineering field (BTE), it is of significant importance to develop bioactive multifunctional scaffolds with enhanced osteoconductivity, osteoinductivity, and antibacterial properties required for lost bone tissue regeneration. In this work, a bioactive glass-ceramic scaffold was manufactured via a novel polymer-derived ceramics (PDC) manufacturing method. To gain antibacterial properties, the silver ions were incorporated in controlled amount along with other precursors in the PDC processing stage. Microstructural and structural properties of the fabricated silicate-phosphate glass-ceramic scaffold were evaluated by scanning electron microscopy (SEM) equipped with energy... 

In the bone tissue engineering field (BTE), it is of significant importance to develop bioactive multifunctional scaffolds with enhanced osteoconductivity, osteoinductivity, and antibacterial properties required for lost bone tissue regeneration. In this work, a bioactive glass-ceramic scaffold was manufactured via a novel polymer-derived ceramics (PDC) manufacturing method. To gain antibacterial properties, the silver ions were incorporated in controlled amount along with other precursors in the PDC processing stage. Microstructural and structural properties of the fabricated silicate-phosphate glass-ceramic scaffold were evaluated by scanning electron microscopy (SEM) equipped with energy... 

Harnessing neural stem cells to repair neuronal damage is a promising potential treatment for neuronal diseases. To enable future therapeutic efficacy, the survival, proliferation, migration and differentiation of neural stem/progenitor cells (NPCs) should be accurately studied and optimized in in vitro platforms before transplanting these cells into the body for treatment purposes. Such studies can determine the appropriate quantities of the biochemical and biomechanical factors needed to control and optimize NPC behavior in vivo. In this study, NPCs were cultured within a microfluidic device while being encapsulated within the collagen matrix. The migration and differentiation of NPCs were... 

The main goal of this study is to consider the simultaneous effect of the surface gradient and the temperature changes on nano-machine migration on gold substrates. By so doing, we hypothesize that nano-machines will experience minimal deviation, which leads them to have a long-range movement even at low temperatures (75 K and 150 K). To this end, the diffusive motion of C60, nanocar, and nanotruck on the conical and concave gold substrates with different radius gradients has been investigated. In order to better understand the effects of chassis and surface interactions on nano-machine movement, an all-atom model and classic atomistic dynamics have been utilized. According to the results,... 

A new semianalytical solution is developed for the velocity-dependent dispersion Henry problem using the Fourier-Galerkin method (FG). The integral arising from the velocity-dependent dispersion term is evaluated numerically using an accurate technique based on an adaptive scheme. Numerical integration and nonlinear dependence of the dispersion on the velocity render the semianalytical solution impractical. To alleviate this issue and to obtain the solution at affordable computational cost, a robust implementation for solving the nonlinear system arising from the FG method is developed. It allows for reducing the number of attempts of the iterative procedure and the computational cost by... 

Existing closed-form solutions of contaminant transport problems are limited by the mathematically convenient assumption of uniform flow. These solutions cannot be used to investigate contaminant transport in coastal aquifers where seawater intrusion induces a variable velocity field. An adaptation of the Fourier-Galerkin method is introduced to obtain semi-analytical solutions for contaminant transport in a confined coastal aquifer in which the saltwater wedge is in equilibrium with a freshwater discharge flow. Two scenarios dealing with contaminant leakage from the aquifer top surface and contaminant migration from a source at the landward boundary are considered. Robust implementation of... 

COMSOL Multiphysics is a comprehensive simulation software environment for a wide range of applications. COMSOL has an interactive interface that facilitates the modeling procedure and allows an easy coupling of different physical processes. The Subsurface Flow module extends the COMSOL modeling environment to applications related to fluid flow in saturated and variably saturated porous media. COMSOL is increasingly used in the investigation of geophysical, hydrogeological and environmental phenomena. The main goal of this work is to explore the ability of COMSOL for simulating seawater intrusion (SWI) in fractured coastal aquifers. Numerical modeling of such a problem is of high interest as... 

Carbon dioxide (CO2) storage in geologic formations is an attractive means of reducing greenhouse gas emissions. The main processes controlling the migration of CO2 in geological formations are related to convective mixing and geochemical reactions. The effects of heterogeneity on these coupled processes have been widely discussed in the literature. Recently, special attention has been devoted to fractured geological formations that can be found in several storage reservoirs. However, existing studies on the effect of fractures on the fate of CO2 neglect the key processes of geochemical reactions. This work aims at addressing this gap. Based on numerical simulations of a hypothetical... 

Let R be a ring and f(x1,..., xn) be a polynomial in noncommutative indeterminates x1,..., xn with coefficients from ℤ and zero constant. The ring R is said to be an f-ring if f(r1,..., rn) = 0 for all r1,..., rn of R and a virtually f-ring if for every n infinite subsets X1,..., Xn (not necessarily distinct) of R, there exist n elements r1 ∈ X1,...,rn ∈ Xn such that f(r1,..., rn) = 0. Let R* be the 'smallest' ring (in some sense) with identity containing R such that Char (R) = Char (R*). Then denote by ZR the subring generated by the identity of R* and denote by f̄R the image of f in ZR [x1,..., xn] (the ring of polynomials with coefficients in ZR in commutative indeterminates x1,..., xn)....